胃的化生——胃癌的前兆？
Metaplasia in the Stomach-Precursor of Gastric Cancer?
机构信息
Graduate School of Medicine, Department of Gastroenterology, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
出版信息
Int J Mol Sci. 2017 Sep 27;18(10):2063. doi: 10.3390/ijms18102063.
Abstract
Despite a significant decrease in the incidence of gastric cancer in Western countries over the past century, gastric cancer is still one of the leading causes of cancer-related deaths worldwide. Most human gastric cancers develop after long-term infection via the Correa pathway: the progression is from gastritis, atrophy, intestinal metaplasia, dysplasia, to cancer. However, it remains unclear whether metaplasia is a direct precursor of gastric cancer or merely a marker of high cancer risk. Here, we review human studies on the relationship between metaplasia and cancer in the stomach, data from mouse models of metaplasia regarding the mechanism of metaplasia development, and the cellular responses induced by infection.
摘要
尽管在过去的一个世纪中，西方国家胃癌的发病率显著下降，但胃癌仍是全球癌症相关死亡的主要原因之一。大多数人类胃癌是在通过科雷亚途径长期感染后发展而来的：其进展过程为胃炎、萎缩、肠上皮化生、异型增生，直至癌症。然而，肠上皮化生是否是胃癌的直接前体，还是仅仅是高癌症风险的标志物，目前仍不清楚。在这里，我们回顾了人类关于胃肠上皮化生与癌症之间关系的研究，以及关于化生发展机制的小鼠模型数据，以及感染引起的细胞反应。
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