无过渡金属参与的 C-N 键形成的去芳构化反应和通过原位释放基于羟胺的胺化试剂的芳基 C-H 胺化反应。
Transition Metal Free C-N Bond Forming Dearomatizations and Aryl C-H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent.
机构信息
School of Chemistry, University of Bristol , Bristol BS8 1TS, United Kingdom.
出版信息
J Am Chem Soc. 2017 Oct 11;139(40):14005-14008. doi: 10.1021/jacs.7b07830. Epub 2017 Sep 27.
Abstract
We outline a simple protocol that accesses directly unprotected secondary amines by intramolecular C-N bond forming dearomatization or aryl C-H amination. The method is dependent on the generation of a potent electrophilic aminating agent released by in situ deprotection of O-Ts activated N-Boc hydroxylamines.
摘要
我们提出了一种简单的方案，可以通过分子内 C-N 键形成去芳构化或芳基 C-H 胺化来直接访问未保护的仲胺。该方法依赖于原位脱保护 O-Ts 活化的 N-Boc 羟胺生成的强亲电胺化剂。
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