Krzak Ada Maria, Cao Jenny Jia Ling, Agius Mark, Hoschl Cyril
Clare College Cambridge, Cambridge, UK.
Psychiatr Danub. 2017 Sep;29(Suppl 3):241-246.
Depression is characterized by atrophy in several brain structures, with the hippocampus seemingly particularly affected. A wide variety of cellular mechanisms have been proposed for these structural modifications, including the regression of dendritic branching. While neurogenesis alone appears inadequate to produce such marked changes, an altered rate is likely to affect hippocampal function. There is also strong evidence for neurotransmitter and glucocorticoid-mediated effects on neurogenesis, providing routes for the action of antidepressants. We aim to show how neurogenesis relates to the 'conventional monoaminergic theory of depression' and its modulation by antidepressants.
抑郁症的特征是多个脑结构萎缩，海马体似乎尤其受到影响。针对这些结构改变已提出了各种各样的细胞机制，包括树突分支的消退。虽然仅神经发生似乎不足以产生如此显著的变化，但神经发生速率的改变可能会影响海马体功能。也有强有力的证据表明神经递质和糖皮质激素对神经发生有介导作用，这为抗抑郁药的作用提供了途径。我们旨在展示神经发生如何与“传统的抑郁症单胺能理论”相关联，以及抗抑郁药对其的调节作用。
