Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Neuropsychopharmacology. 2011 Dec;36(13):2589-602. doi: 10.1038/npp.2011.220. Epub 2011 Sep 21.
The neurogenesis hypothesis of depression posits (1) that neurogenesis in the subgranular zone of the dentate gyrus is regulated negatively by stressful experiences and positively by treatment with antidepressant drugs and (2) that alterations in the rate of neurogenesis play a fundamental role in the pathology and treatment of major depression. This hypothesis is supported by important experimental observations, but is challenged by equally compelling contradictory reports. This review summarizes the phenomenon of adult hippocampal neurogenesis, the initial and continued evidence leading to the development of the neurogenesis hypothesis of depression, and the recent studies that have disputed and/or qualified those findings, to conclude that it can be affected by stress and antidepressants under certain conditions, but that these effects do not appear in all cases of psychological stress, depression, and antidepressant treatment.
（1） 齿状回颗粒下层的神经发生受到应激体验的负向调节，而受到抗抑郁药物的正向调节；（2） 神经发生率的改变在重度抑郁症的发病机制和治疗中起根本作用。这一假说得到了重要的实验观察结果的支持，但也受到了同样有力的相反报告的挑战。本综述总结了成年海马神经发生的现象，导致抑郁症神经发生假说发展的初步和持续证据，以及最近对这些发现提出质疑和/或限定的研究，得出的结论是，在某些条件下，它可以受到应激和抗抑郁药的影响，但这些影响并非出现在所有的心理应激、抑郁症和抗抑郁治疗病例中。
