Włodarczyk Adam, Szarmach Joanna, Jakuszkowiak-Wojten Katarzyna, Gałuszko-Węgielnik Maria, Wiglusz Mariusz S
Department of Psychiatry, Medical University of Gdańsk, Dębinki St. 7 build. 25, 80-952 Gdańsk, Poland.
Psychiatr Danub. 2017 Sep;29(Suppl 3):341-344.
Neurosyphilis is an infection of the brain or spinal cord caused by Treponema pallidum. In the third phase of syphilis involving the central nervous system it may manifest in a widespread dysfunctions including psychiatric manifestations being often underestimated in the differential diagnosis.
Two patients demonstrating rapid cognitive decline as the primary symptom for neurosyphillis are described with particular focus on the diagnostic process complexity and adequate treatment delivery.
Clinical manifestations as well as psychiatric symptoms of syphilis are diverse and often non-specific. The symptomatology of mood disorders in neurosyphilis is frequently atypical, intermittent, and pleomorphic and fails to meet DSM-5 diagnostic categories. Neurocognitive decline although could be one of the key symptoms domains in neurosyphilis. Those two cases emphasise the importance of specific differential diagnosis with rapid onset cognitive decline with spotlight to sexually transmitted diseases as syphilis.
神经梅毒是由梅毒螺旋体引起的脑或脊髓感染。在梅毒累及中枢神经系统的第三阶段，它可能表现为广泛的功能障碍，包括精神症状，在鉴别诊断中常常被低估。
描述了两名以快速认知衰退为神经梅毒主要症状的患者，特别关注诊断过程的复杂性和适当治疗的实施。
梅毒的临床表现以及精神症状多种多样且往往不具特异性。神经梅毒中情绪障碍的症状学常常是非典型的、间歇性的和多形性的，不符合《精神疾病诊断与统计手册》第5版的诊断类别。尽管神经认知衰退可能是神经梅毒的关键症状领域之一。这两个病例强调了对快速起病的认知衰退进行特异性鉴别诊断的重要性，尤其要关注梅毒等性传播疾病。
