Jakuszkowiak-Wojten Katarzyna, Raczak Alicja, Landowski Jerzy, Wiglusz Mariusz Stanisław, Gałuszko-Węgielnik Maria, Krysta Krzysztof, Cubała Wiesław Jerzy
Department of Psychiatry, Medical University of Gdańsk, Dębinki St. 7 build. 25, 80-952 Gdańsk, Poland,
Psychiatr Danub. 2017 Sep;29(Suppl 3):353-356.
The impaired decision-making with high risk-aversive behavior and elevated impulsivity are reported as a trait feature in anxiety disorders including panic disorder (PD). It is hypothesised that PD patients exhibit difficulties in executive functions which can influence patients behavioural strategies e.g. problem solving, decision making, planning, impulse control. The aim of this study was to asses decision making process, risk-taking and impulsivity in PD patients as compared to healthy controls.
Twenty-one psychotropic drug-naive PD outpatients and 20 healthy subjects matched by age and sex were examined. Cognitive decision-making and risk-taking behaviour was measured with CGT (Cambridge Gambling Task) from CANTAB battery. The PD severity was assessed with Panic and Agoraphobia Scale (PAS). The level of anxiety and depression was assessed with HADS (Hospital Anxiety and Depression Scale). Impulsivity was evaluated with the Barratt Impulsiveness Scale, 11 version (BIS-11).
There were no statistically significant differences on CGT in PD patients as compared to healthy control. However, having observed more closely, there are some differences between patients and healthy control. PD patients with higher anxiety level in HADS exhibited lower percentages of risky decisions comparing to PD with lower anxiety in HADS. PD patients with higher depression level in HADS demonstrated slowed decision-making when compared to PD patients with low level of depression in HADS. Total impulsivity and its attentional and motor dimensions were significantly higher in panic disorder patients versus healthy controls.
There were no statistically significant differences with regard to CGT assessed decision-making between drug-naive PD patients and healthy controls. The PD patients with higher HADS-D depression level demonstrated slowed decision-making as compared to PD patients with low level of depression.
据报道，包括惊恐障碍（PD）在内的焦虑症患者存在决策受损、高风险规避行为和冲动性增加等特质特征。据推测，PD患者在执行功能方面存在困难，这可能会影响患者的行为策略，如解决问题、决策、规划和冲动控制。本研究的目的是评估PD患者与健康对照者的决策过程、冒险行为和冲动性。
对21名未服用过精神药物的PD门诊患者和20名年龄和性别匹配的健康受试者进行了检查。使用剑桥神经心理测试自动化成套系统（CANTAB）中的剑桥赌博任务（CGT）测量认知决策和冒险行为。用惊恐和广场恐怖症量表（PAS）评估PD的严重程度。用医院焦虑抑郁量表（HADS）评估焦虑和抑郁水平。用Barratt冲动性量表第11版（BIS-11）评估冲动性。
与健康对照相比，PD患者在CGT上无统计学显著差异。然而，经过更仔细的观察，患者与健康对照之间存在一些差异。与HADS焦虑水平较低的PD患者相比，HADS焦虑水平较高的PD患者做出冒险决策的百分比更低。与HADS抑郁水平较低的PD患者相比，HADS抑郁水平较高的PD患者决策速度较慢。惊恐障碍患者的总冲动性及其注意力和运动维度显著高于健康对照。
未服用过药物的PD患者与健康对照在CGT评估的决策方面无统计学显著差异。与抑郁水平较低的PD患者相比，HADS-D抑郁水平较高的PD患者决策速度较慢。
