Najim Hellme, Pathak Ashish, Pathak Andrea
Essex University Foundation NHS Trust, UK,
Psychiatr Danub. 2017 Sep;29(Suppl 3):652-655.
Adherence to treatment is a major issue in relapse prevention in schizophrenia. Injectable depot has been claimed to improve non-adherence. A study in the North of England has shown that risperidone long acting injectable form has reduced number of admissions and number of days stayed in hospital. Our study aimed to replicate the previous study in the South of England.
A retrospective study was conducted in the South Essex Foundation University NHS trust. We selected every fifth patient on the Hospital Pharmacy list for risperidone long acting injectable (RLAI). We collected information on. Age, sex, diagnosis and medication ,regular follow up, investigation of each patient which included weight, FBS, S. lipid and hormones at the start of treatment, at three months and six months intervals. We recorded reasons for starting RLAI. Number of antipsychotics prescribed before RLAI, illness duration, number of admissions and days stayed in hospital in each episode before and after RLAI. Patients were included if they stayed for one year or on RLAI.
We reviewed 65 case notes. The most common reason for starting RLAI was non compliance. 80% of our sample had the illness for more than five years. Half of them had physical morbidity. After RLAI was commenced there was a significant association with number and length of admissions.
We have found an association between prescription of RLAI and reduction in number and length of admission. This needs to be confirmed in a randomised controlled trial.
坚持治疗是精神分裂症预防复发的一个主要问题。长效注射剂据称可改善治疗依从性。英格兰北部的一项研究表明，利培酮长效注射剂减少了住院次数和住院天数。我们的研究旨在在英格兰南部重复先前的研究。
在南埃塞克斯基础大学国民保健服务信托基金进行了一项回顾性研究。我们从医院药房名单中每隔五位选择一名使用利培酮长效注射剂（RLAI）的患者。我们收集了以下信息：年龄、性别、诊断和用药情况、定期随访情况，对每位患者在治疗开始时、每隔三个月和六个月进行的检查，包括体重、空腹血糖、血脂和激素水平。我们记录了开始使用RLAI的原因。在使用RLAI之前开具的抗精神病药物数量、病程、在使用RLAI之前和之后每次发作的住院次数和住院天数。如果患者使用RLAI达一年或以上，则纳入研究。
我们查阅了65份病例记录。开始使用RLAI的最常见原因是不依从。我们样本中的80%患有该疾病超过五年。其中一半有躯体疾病。开始使用RLAI后，住院次数和住院时间存在显著关联。
我们发现使用RLAI与住院次数和住院时间的减少之间存在关联。这需要在随机对照试验中得到证实。
