a College of Pharmacy, College (Institute) of Intergrative Medicine, The Second Affiliated Hospital of Dalian Medical University , Dalian Medical University , Dalian , China.
b Chinese People's Liberation Army 210 Hospital , Dalian , China.
Nat Prod Res. 2018 Dec;32(23):2749-2755. doi: 10.1080/14786419.2017.1380024. Epub 2017 Sep 28.
The chemical constituent investigation of - subsp has led to isolation and identification of thirteen compounds, including one new sesquiterpene, (10)-11-hydroxy--cyperone (), three sesquiterpenes (-), five phenylpropanoids (-), and four alkaloids (-). We report herein, for the first time, the presence of compounds - in the genus . Their structures were established using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were assayed for their inhibitory activities against nitric oxide production in LPS-induced RAW 264.7 cells and antioxidant activities by DPPH scavenging assay. Compounds - displayed significant inhibitory effects against NO production at a certain concentration, while compound showed antioxidant activity with IC of 55.28 μM. The interactions of compounds , , and with iNOS were investigated using molecular docking.
