蛋白质组学鉴定出高尔基体磷蛋白 3（GOLPH3）与高尔基体结构、癌症、DNA 损伤以及防止细胞死亡之间存在关联。
Proteomics Identifies Golgi phosphoprotein 3 (GOLPH3) with A Link Between Golgi Structure, Cancer, DNA Damage and Protection from Cell Death.
机构信息
From the ‡Department of Medicine, McGill University Hospital Research Institute, Montreal, Quebec, Canada H4A 3J1;
From the ‡Department of Medicine, McGill University Hospital Research Institute, Montreal, Quebec, Canada H4A 3J1.
出版信息
Mol Cell Proteomics. 2017 Dec;16(12):2048-2054. doi: 10.1074/mcp.MR117.000068. Epub 2017 Sep 27.
Abstract
GOLPH3 is the first example of a Golgi resident oncogene protein. It was independently identified in multiple screens; first in proteomic-based screens as a resident protein of the Golgi apparatus, and second as an oncogene product in a screen for genes amplified in cancer. A third screen uncovered the association of GOLPH3 with the Golgi resident phospholipid, phosphatidyl inositol 4 phosphate (PI4P) to maintain the characteristic ribbon structure of the Golgi apparatus favoring vesicular transport of secretory proteins.
摘要
GOLPH3 是第一个被鉴定的定位于高尔基体的致癌基因蛋白。它是通过多种筛选方法独立鉴定出来的：首先在基于蛋白质组学的筛选中，它被鉴定为高尔基体的固有蛋白，其次在筛选扩增的癌基因产物中，它被鉴定为致癌基因蛋白。第三次筛选揭示了 GOLPH3 与高尔基体驻留磷脂酰肌醇 4 磷酸（PI4P）的关联，以维持高尔基体的特征带状结构，有利于分泌蛋白的囊泡运输。
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