Makowski Stefanie L, Tran Thuy Tt, Field Seth J
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, CA 92093-0707, USA.
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, CA 92093-0707, USA.
Curr Opin Cell Biol. 2017 Apr;45:17-23. doi: 10.1016/j.ceb.2017.01.004. Epub 2017 Feb 16.
The Golgi is generally recognized for its central role in the secretory pathway to orchestrate protein post-translational modification and trafficking of proteins and lipids to their final destination. Despite the common view of the Golgi as an inert sorting organelle, emerging data demonstrate that important signaling events occur at the Golgi, including those that regulate the trafficking function of the Golgi. The phosphatidylinositol-4-phosphate/GOLPH3/MYO18A/F-actin complex serves as a hub for signals that regulate Golgi trafficking function. Furthermore, the Golgi is increasingly appreciated for its important role in cell growth and in driving oncogenic transformation, as illuminated by the discovery that GOLPH3 and MYO18A are cancer drivers.
高尔基体通常因其在分泌途径中的核心作用而被认可，它负责协调蛋白质的翻译后修饰以及蛋白质和脂质向其最终目的地的运输。尽管人们普遍认为高尔基体是一个惰性的分拣细胞器，但新出现的数据表明，重要的信号事件发生在高尔基体，包括那些调节高尔基体运输功能的事件。磷脂酰肌醇-4-磷酸/GOLPH 3/MYO18A/F-肌动蛋白复合物是调节高尔基体运输功能信号的枢纽。此外，高尔基体在细胞生长和驱动致癌转化中的重要作用越来越受到重视，这一点从GOLPH3和MYO18A是癌症驱动因素这一发现中得到了体现。
