Kuroda Masashi, Sakaue Hiroshi
Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School.
J Med Invest. 2017;64(3.4):193-196. doi: 10.2152/jmi.64.193.
Cell death is closely linked to many diseases including cancer, neurodegenerative diseases, autoimmune diseases, and metabolic disorders. Increased adipocyte death has been reported during the development of obesity. Adipocyte death may be caused by excessive stress during obesity-related adipose tissue remodeling. Adipose tissue macrophages are key players in obesity-related inflammation and systemic insulin resistance. Accumulating evidence suggests that adipocyte death is involved in immune cell function and initiates inflammation through an interaction with macrophages; however, the precise mechanisms remain largely unknown. This review focuses on the contribution of dead cells (particularly dead adipocytes in adipose tissue) to the pathophysiological conditions associated with obesity. J. Med. Invest. 64: 193-196, August, 2017.
细胞死亡与许多疾病密切相关，包括癌症、神经退行性疾病、自身免疫性疾病和代谢紊乱。据报道，在肥胖症发展过程中脂肪细胞死亡增加。脂肪细胞死亡可能是由肥胖相关脂肪组织重塑过程中的过度应激引起的。脂肪组织巨噬细胞是肥胖相关炎症和全身胰岛素抵抗的关键参与者。越来越多的证据表明，脂肪细胞死亡参与免疫细胞功能，并通过与巨噬细胞的相互作用引发炎症；然而，确切机制仍 largely 未知。本综述重点关注死亡细胞（特别是脂肪组织中的死亡脂肪细胞）对与肥胖相关的病理生理状况的影响。《医学调查杂志》64: 193 - 196，2017年8月。
