Meriño Miguel, Briones Lautaro, Palma Verónica, Herlitz Kurt, Escudero Carlos
Laboratorio de Fisiología Vascular, Grupo de Investigación en Angiogénesis Tumoral (GIANT), Departamento de Ciencias Básicas, Universidad del Bio Bio, Chillán, Chile.
Laboratorio de Fisiología Vascular, Grupo de Investigación en Angiogénesis Tumoral (GIANT), Departamento de Ciencias Básicas, Universidad del Bio Bio, Chillán, Chile; Departamento de Nutrición y Salud Pública, Facultad de Ciencias de la Salud y los Alimentos, Universidad del Bio Bio, Chillán, Chile.
Endocrinol Diabetes Nutr. 2017 Jun-Jul;64(6):317-327. doi: 10.1016/j.endinu.2017.03.010. Epub 2017 May 16.
Lipoinflamation is the inflammation generated in the adipose tissue. It can contribute to the development of insulin resistance. The lipoinflammation-associated mechanisms are related to the function of adipocytes and macrophages present in the adipose tissue. In this regard, the level of nucleoside adenosine is increased in individuals with obesity. Causes or consequences of this increase are unknown. Although, adenosine activating its receptors (A, A, A and A) is able to differentially modulate the function of adipocytes and macrophages, in order to avoid the reduction of insulin sensitivity and generate an anti-inflammatory state in subject with obesity. In this review we propose that adenosine could be a key element in the development of new strategies for limit lipoinflammation and regulate metabolic homeostasis through modulation of adipocyte-macrophage dialogue.
脂肪组织炎症是在脂肪组织中产生的炎症。它会促进胰岛素抵抗的发展。与脂肪组织炎症相关的机制与脂肪组织中存在的脂肪细胞和巨噬细胞的功能有关。在这方面，肥胖个体中核苷腺苷的水平会升高。这种升高的原因或后果尚不清楚。尽管腺苷激活其受体（A1、A2A、A2B和A3）能够差异性地调节脂肪细胞和巨噬细胞的功能，以避免肥胖受试者胰岛素敏感性降低并产生抗炎状态。在本综述中，我们提出腺苷可能是制定新策略以限制脂肪组织炎症并通过调节脂肪细胞-巨噬细胞对话来调节代谢稳态的关键因素。
