Dar Mudassir Iqbal, Dar Asim Hassan, Ahmed Mansoor, Haseeb Abdul, Bilal Muhammad
Department of Cardiac Surgery, Dow Medical College, Dow University of Health Sciences.
Faculty of Pharmacy, University of Karachi.
J Pak Med Assoc. 2017 Oct;67(10):1558-1561.
To find out any differences in free flow of internal mammary artery among different ethnic groups.
This observational, cross-sectional study was conducted at the Civil Hospital, Karachi, from January 2013 to December 2015, and comprised patients who underwent coronary artery bypass grafting. The participants were divided into 5 groups, i.e. Sindhi, Muslim migrants from India, Punjabi, Pathan and Balochi patients. Free flow of internal mammary artery was measured immediately after harvesting within a syringe, and its flow was measured in 30 seconds. SPSS 18 was used for data analysis.
Of the 158 patients, 44(27.8%) were Sindhi, 33(20.9%) Punjabi, 8(5%) Baloch, 21(13.3%) Pathan and 52(32.9%) were migrants. The overall mean age was 52±8 years and the mean flow was 11.6±9.6ml per 30 seconds. The flow was 9.3±6 ml, 10±8ml, 13±11ml, 17±14ml and 15±13 ml in 30 seconds among migrants, Sindhi, Punjabi, Pathan and Baloch patients, respectively, with significant higher flow in Pathan patients compared to Sindhi and migrant patients (p<0.05). A flow of less than 5ml/30 sec was mostly found in migrants or Sindhi subjects 30/40(75%), and flow more than 30ml/ 30 seconds was found mostly in Baloch or Pathan patients 4/8(50%). Low flow internal mammary artery, which was used on left anterior descending artery, showed significantly higher need of inotropic support as compared to high flow internal mammary artery (p=0.004), more low cardiac output syndrome (p=0.022) and more use of intra-aortic balloon pump (p=0.028).
Internal mammary artery flow was higher in Pathan and Baloch patients and low in migrants and Sindhis.
探究不同种族群体乳内动脉自由血流情况的差异。
本观察性横断面研究于2013年1月至2015年12月在卡拉奇市民医院开展，纳入接受冠状动脉旁路移植术的患者。参与者被分为5组，即信德族、来自印度的穆斯林移民、旁遮普族、普什图族和俾路支族患者。乳内动脉在采集后立即置于注射器中测量其自由血流，并在30秒内测量其流量。采用SPSS 18进行数据分析。
158例患者中，44例（27.8%）为信德族，33例（20.9%）为旁遮普族，8例（5%）为俾路支族，21例（13.3%）为普什图族，52例（32.9%）为移民。总体平均年龄为52±8岁，平均流量为每30秒11.6±9.6毫升。移民、信德族、旁遮普族、普什图族和俾路支族患者30秒内的流量分别为9.3±6毫升、10±8毫升、13±11毫升、17±14毫升和15±13毫升，普什图族患者的流量显著高于信德族和移民患者（p<0.05）。30/40（75%）的移民或信德族受试者大多出现每30秒流量低于5毫升的情况，4/8（50%）的俾路支族或普什图族患者大多出现每30秒流量超过30毫升的情况。用于左前降支动脉的低流量乳内动脉与高流量乳内动脉相比，显示出显著更高的强心支持需求（p=0.004）、更多的心排血量低综合征（p=0.022）以及更多的主动脉内球囊泵使用（p=0.028）。
普什图族和俾路支族患者的乳内动脉血流较高，而移民和信德族患者的血流较低。
