头颈部鳞状细胞癌中的人乳头瘤病毒：对马拉维利隆圭卡穆祖中央医院经组织学确诊病例的描述性研究。
Human papillomavirus in head and neck squamous cell carcinoma: A descriptive study of histologically confirmed cases at Kamuzu Central Hospital in Lilongwe, Malawi.
作者信息
Faggons Claire E, Mabedi Charles E, Liomba N George, Funkhouser William K, Chimzimu Fred, Kampani Coxcilly, Krysiak Robert, Msiska Nelson, Shores Carol G, Gopal Satish
机构信息
UNC Project-Malawi, Lilongwe, Malawi.
Department of Surgery, Kamuzu Central Hospital, Lilongwe, Malawi.
出版信息
Malawi Med J. 2017 Jun;29(2):142-145. doi: 10.4314/mmj.v29i2.12.
BACKGROUND
Head and neck squamous cell carcinoma (HNSCC) is common in sub-Saharan Africa, but the aetiologic contribution of human papillomavirus (HPV) is not well established.
METHODS
We assessed HNSCC cases for HPV using p16 immunohistochemistry (IHC) in Malawi. Associations between p16 IHC and tumour site, behavioural risk factors, demographic characteristics, and HIV status were examined.
RESULTS
From 2010 to 2014, 77 HNSCC cases were identified. Mean age was 52 years, 50 cases (65%) were male, and 48 (62%) were in the oropharynx (OP) or oral cavity (OC). HIV status was known for 35 patients (45%), with 5 (14%) HIV-infected. Substance use was known for 40 patients (52%), with 38% reporting any tobacco and 31% any alcohol. Forty-two cases (55%) had adequate tissue for p16 IHC, of which seven (17%) were positive, including 22% of OP/OC tumours.
CONCLUSIONS
Despite high cervical cancer burden, HPV-associated HNSCC is not very common in Malawi.
背景
头颈部鳞状细胞癌（HNSCC）在撒哈拉以南非洲地区很常见，但人乳头瘤病毒（HPV）的病因学作用尚未完全明确。
方法
我们在马拉维使用p16免疫组织化学（IHC）评估HNSCC病例中的HPV情况。研究了p16 IHC与肿瘤部位、行为危险因素、人口统计学特征和HIV状态之间的关联。
结果
2010年至2014年期间，共确定了77例HNSCC病例。平均年龄为52岁，50例（65%）为男性，48例（62%）发生于口咽（OP）或口腔（OC）。35例患者（45%）的HIV状态已知，其中5例（14%）感染HIV。40例患者（52%）的物质使用情况已知，38%报告有任何烟草使用，31%报告有任何酒精使用。42例（55%）有足够组织用于p16 IHC检测，其中7例（17%）为阳性，包括OP/OC肿瘤的22%。
结论
尽管宫颈癌负担较重，但在马拉维，HPV相关的HNSCC并不常见。
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