Chorba T L, Kalyanaraman V S, Lacher M J, Schulof R S
Division of Field Services, Centers for Disease Control, Atlanta, GA 30333.
Am J Hematol. 1988 Jan;27(1):13-6. doi: 10.1002/ajh.2830270104.
Because of the T-cell abnormalities observed in Hodgkin's disease and the growing number of Hodgkin's disease cases observed in association with the acquired immunodeficiency syndrome (AIDS), concern has been expressed that a retrovirus may be the primary cause of Hodgkin's disease. We examined plasma specimens from 17 patients with Hodgkin's disease that were drawn in 1979. Because serum containing antibodies to either human T-lymphotropic virus type I (HTLV-I) or HTLV-II precipitate the major core protein, p24, of HTLV-I, lack of reactivity to HTLV-I p24 in all the specimens demonstrated absence of antibodies to HTLV-I or -II. None of the specimens was reactive to human immunodeficiency virus type 1 (HIV-1) by ELISA. None of the specimens were reactive on Western blot assays for HTLV-I or -II or HIV-1. Lack of evidence of cross-reacting antibodies to prototype strains of those retroviruses in specimens drawn before the AIDS epidemic suggests that classic Hodgkin's disease is not the result of infection with one of the known human lymphocytotropic retroviruses or a closely related agent.
由于在霍奇金病中观察到T细胞异常，且与获得性免疫缺陷综合征（AIDS）相关的霍奇金病病例数量不断增加，有人担心逆转录病毒可能是霍奇金病的主要病因。我们检测了1979年采集的17例霍奇金病患者的血浆样本。由于含有人T淋巴细胞白血病病毒I型（HTLV-I）或HTLV-II抗体的血清会沉淀HTLV-I的主要核心蛋白p24，所有样本中对HTLV-I p24无反应表明不存在针对HTLV-I或-II的抗体。通过酶联免疫吸附测定（ELISA），没有一个样本对1型人类免疫缺陷病毒（HIV-1）有反应。在针对HTLV-I或-II以及HIV-1的蛋白质印迹分析中，没有一个样本有反应。在艾滋病流行之前采集的样本中缺乏针对这些逆转录病毒原型株的交叉反应抗体的证据，这表明经典霍奇金病不是由已知的人类嗜淋巴细胞逆转录病毒之一或密切相关病原体感染所致。
