基于白蛋白-孢粉素作为药物载体的阿霉素负载平台的开发。
Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier.
作者信息
Maltas Esra, Gubbuk Ilkay Hilal, Yildiz Salih
机构信息
Department of Chemistry, Selcuk University, 42075 Konya, Turkey.
Department of Biochemistry, Selcuk University, 42075 Konya, Turkey.
出版信息
Biochem Biophys Rep. 2016 Jun 16;7:201-205. doi: 10.1016/j.bbrep.2016.06.012. eCollection 2016 Sep.
Albumin is thought as an drug carrier for doxorubicin (DOX). The binding of doxorubicin to albumin was studied on the surface of sporopolleninin (SP) to produce a new drug system based natural materials. Human serum albumin (HSA) was immobilized on SPIONs in 20 mM Tris buffer, 7.4 of pH. Data showed that binding amount of HSA has been found to be as 285.53 µg to the 25 mg of Sporopolleninin which also bounded 319.76 µM of DOX. Binding of protein and drug to Sp were clarified by SEM, EDX and FT-IR analysis.
白蛋白被认为是阿霉素（DOX）的药物载体。研究了阿霉素与白蛋白在孢粉素（SP）表面的结合情况，以制备一种基于天然材料的新型药物系统。在pH为7.4的20 mM Tris缓冲液中，将人血清白蛋白（HSA）固定在超顺磁性氧化铁纳米颗粒（SPIONs）上。数据显示，已发现25 mg孢粉素上HSA的结合量为285.53 μg，其还结合了319.76 μM的阿霉素。通过扫描电子显微镜（SEM）、能量散射X射线谱（EDX）和傅里叶变换红外光谱（FT-IR）分析阐明了蛋白质和药物与孢粉素的结合情况。
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