Kabasakalian Anahid, Ferretti Casara J, Hollander Eric
Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Ferkauf Graduate School of Psychology, Yeshiva University, Albert Einstein College of Medicine, Bronx, NY, USA.
Curr Top Behav Neurosci. 2018;35:529-557. doi: 10.1007/7854_2017_28.
In the chapter, we explore the relationship between the peptide hormone, oxytocin (OT), and behavioral and metabolic disturbances observed in the genetic disorder Prader-Willi Syndrome (PWS). Phenotypic and genotypic characteristics of PWS are described, as are the potential implications of an abnormal OT system with respect to neural development including the possible effects of OT dysfunction on interactions with other regulatory mediators, including neurotransmitters, neuromodulators, and hormones. The major behavioral characteristics are explored in the context of OT dysfunction, including hyperphagia, impulsivity, anxiety and emotion dysregulation, sensory processing and interoception, repetitive and restrictive behaviors, and dysfunctional social cognition. Behavioral overlaps with autistic spectrum disorders are discussed. The implications of OT dysfunction on the mechanisms of reward and satiety and their possible role in informing behavioral characteristics are also discussed. Treatment implications and future directions for investigation are considered.
在本章中，我们探讨了肽类激素催产素（OT）与遗传性疾病普拉德-威利综合征（PWS）中观察到的行为和代谢紊乱之间的关系。描述了PWS的表型和基因型特征，以及OT系统异常对神经发育的潜在影响，包括OT功能障碍对与其他调节介质（包括神经递质、神经调质和激素）相互作用的可能影响。在OT功能障碍的背景下探讨了主要行为特征，包括食欲亢进、冲动、焦虑和情绪失调、感觉处理和内感受、重复和刻板行为以及功能失调的社会认知。讨论了与自闭症谱系障碍的行为重叠。还讨论了OT功能障碍对奖赏和饱腹感机制的影响及其在解释行为特征方面的可能作用。考虑了治疗意义和未来的研究方向。
