Zhao Juping, Sun Yicheng
Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Sheng Wu Gong Cheng Xue Bao. 2017 Sep 25;33(9):1513-1524. doi: 10.13345/j.cjb.170073.
Yersinia pestis, the cause of plague, is transmitted by flea bite. Y. pestis forms a biofilm in the proventriculus of its flea vector to enhance transmission. Biofilm formation in Y. pestis is positively regulated by the intracellular levels of the second messenger cyclic diguanylate (c-di-GMP). The c-di-GMP in Y. pestis is synthesized by two diguanylate cyclases (DGC), HmsT and HmsD, and degraded by phosphodiesterase (PDE), HmsP. Here we summarized the regulators that modulate c-di-GMP metabolism and biofilm formation in Y. pestis and discussed their regulatory mechanism.
鼠疫耶尔森菌是鼠疫的病原体，通过跳蚤叮咬传播。鼠疫耶尔森菌在其跳蚤媒介的前胃中形成生物膜以增强传播。鼠疫耶尔森菌中的生物膜形成受到第二信使环二鸟苷酸（c-di-GMP）细胞内水平的正向调节。鼠疫耶尔森菌中的c-di-GMP由两种二鸟苷酸环化酶（DGC），即HmsT和HmsD合成，并由磷酸二酯酶（PDE）HmsP降解。在此，我们总结了调节鼠疫耶尔森菌中c-di-GMP代谢和生物膜形成的调节因子，并讨论了它们的调节机制。
