Xie Zhoujie, Zhang Zhao, Liu Liwei, Liu Xiaochen, Chen Yihua
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Sheng Wu Gong Cheng Xue Bao. 2017 Sep 25;33(9):1547-1554. doi: 10.13345/j.cjb.170046.
Dental biofilms are composed of hundreds of bacterial species, among which Streptococcus mutans is widely recognized as the major pathogen of dental caries. The cariogenic potential of S. mutans is related to its ability to form a robust biofilm on the tooth surface and its acidogenic and acid-tolerant properties. Co-evolution of S. mutans with the host has resulted in the diversity of secondary metabolism of S. mutans in strain level. A variety of secondary metabolites, including 10 bacteriocins (mutacins) and one hybrid Polyketide/Non-Ribosomal Peptide type compound, have been characterized. Studies on these secondary metabolites indicate that they play a significant role either in interspecies or in inter-kingdom interactions in the dental biofilm. As more S. mutans strains are isolated and sequenced, additional secondary metabolites with novel functions will be discovered. The study of secondary metabolites in S. mutans is anticipated to be helpful for oral disease treatment and prevention by providing new strategies.
牙菌斑由数百种细菌组成，其中变形链球菌被广泛认为是龋齿的主要病原体。变形链球菌的致龋潜力与其在牙齿表面形成坚固生物膜的能力以及产酸和耐酸特性有关。变形链球菌与宿主的共同进化导致了菌株水平上变形链球菌次生代谢的多样性。已经鉴定出多种次生代谢产物，包括10种细菌素（变链菌素）和一种杂合聚酮/非核糖体肽类化合物。对这些次生代谢产物的研究表明，它们在牙菌斑的种间或跨界相互作用中发挥着重要作用。随着更多变形链球菌菌株的分离和测序，将发现具有新功能的其他次生代谢产物。预计对变形链球菌次生代谢产物的研究将通过提供新策略有助于口腔疾病的治疗和预防。
