Genetta T L, D'Eustachio P, Kadner S S, Finlay T H
Department of Environmental Medicine, New York University Medical Center, New York 10016.
Biochem Biophys Res Commun. 1988 Mar 30;151(3):1364-70. doi: 10.1016/s0006-291x(88)80513-8.
We report here the cloning of a partial cDNA for Esterase 1, the major esterase activity in mouse plasma. A 470 base pair insert was isolated from a lambda gt11 cDNA library constructed from mouse liver poly A+ RNA, and identified by hybrid selected translation. We show that the sexual dimorphism displayed in the plasma levels of this protein is caused by a difference at the level of transcription. In addition, RFLP data using mouse recombinant inbred strains mapped this clone at the Es-1 locus on mouse chromosome 8.
