Delaney Conor, Campbell Matthew
a Smurfit Institute of Genetics, Trinity College Dublin , Dublin , Ireland.
Tissue Barriers. 2017 Oct 2;5(4):e1373897. doi: 10.1080/21688370.2017.1373897. Epub 2017 Sep 28.
The blood brain barrier is a necessity for cerebral homeostasis and response to environmental insult, thus loss in functionality with age creates opportunities for disease to arise in the aged brain. Understanding how the barrier is developed and maintained throughout the earlier years of adult life can identify key processes that may have beneficial applications in the restoration of the aged brain. With an unprecedented increasing global aged population, the prevention and treatment of age-associated disorders has become a rising healthcare priority demanding novel approaches for the development of therapeutic strategies. The aging cardiovascular system has long been recognised to be a major factor in age-associated diseases such as stroke, atherosclerosis and cardiac arrest. Changes in the highly specialised cerebral vasculature may similarly drive neurodegenerative and neuropsychiatric disease.
血脑屏障对于大脑内环境稳定和应对环境损伤至关重要，因此随着年龄增长其功能丧失会为老年大脑疾病的发生创造条件。了解在成年早期血脑屏障是如何发育和维持的，能够确定一些关键过程，这些过程可能在老年大脑恢复方面具有有益应用。随着全球老年人口前所未有的增长，预防和治疗与年龄相关的疾病已成为日益重要的医疗保健重点，需要新的方法来制定治疗策略。长期以来，衰老的心血管系统一直被认为是中风、动脉粥样硬化和心脏骤停等与年龄相关疾病的主要因素。高度特化的脑血管变化同样可能引发神经退行性疾病和神经精神疾病。
