Department for Neonatology, Charité University Medical Center, Chariteplatz 1, 10117, Berlin, Germany; Cellular Oncology Group, Biodonostia Health Research Institute, Paseo Doctor Begiristain, 20014, San Sebastian, Spain.
Department for Neonatology, Charité University Medical Center, Chariteplatz 1, 10117, Berlin, Germany.
Mech Ageing Dev. 2019 Oct;183:111147. doi: 10.1016/j.mad.2019.111147. Epub 2019 Sep 4.
The objective of this paper is to review current information regarding astrocytes function after a stroke in neonatal and adult brain. Based on the current literature, there are some molecular differences related to blood brain barrier (BBB) homeostasis disruption, inflammation and reactive oxygen species (ROS) mediated injury between the immature and mature brain after an ischemic event. In particular, astrocytes, the main glial cells in brain, play a different role in neonatal and adult brain after stroke, as time course of glial activation is strongly age dependent. Moreover, the present review provides further insight into the therapeutic approaches of using neonatal and adult astrocytes after stroke. More research will be needed in order to translate them into an effective treatment against stroke, the second main cause of death and disability worldwide.
本文旨在综述目前关于新生儿和成人脑中风后星形胶质细胞功能的相关信息。基于目前的文献，在缺血事件后，未成熟和成熟大脑之间与血脑屏障（BBB）稳态破坏、炎症和活性氧（ROS）介导的损伤相关的分子存在一些差异。具体而言，星形胶质细胞是大脑中的主要神经胶质细胞，在中风后在新生儿和成人的大脑中发挥不同的作用，因为神经胶质细胞激活的时间过程强烈依赖于年龄。此外，本综述还进一步深入探讨了使用新生儿和成人星形胶质细胞治疗中风的治疗方法。为了将它们转化为有效的中风治疗方法（全球第二大致死和致残的原因），还需要进行更多的研究。
