用于巨噬细胞特异性靶向和光热消融的一氧化氮可激活金纳米颗粒。
Nitric oxide-activatable gold nanoparticles for specific targeting and photo-thermal ablation of macrophages.
作者信息
Park Junghong, Pramanick Swapan, Kim Jinhwan, Lee Jihyun, Kim Won Jong
机构信息
Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea.
出版信息
Chem Commun (Camb). 2017 Oct 18;53(81):11229-11232. doi: 10.1039/c7cc06420a. Epub 2017 Sep 28.
In this study, we designed NO-activatable gold nanoparticles (NAM-AuNPs) for specific targeting and photo-thermal ablation of macrophages. The gold nanoparticles showed aggregation behavior in response to NO solution as well as endogenous NO secreted from activated macrophages. Following NIR irradiation, significant cytotoxicity was observed in activated RAW 264.7 cells treated with NAM-AuNPs.
在本研究中，我们设计了可被一氧化氮（NO）激活的金纳米颗粒（NAM-AuNPs），用于巨噬细胞的特异性靶向和光热消融。金纳米颗粒对NO溶液以及活化巨噬细胞分泌的内源性NO表现出聚集行为。在近红外（NIR）照射后，用NAM-AuNPs处理的活化RAW 264.7细胞中观察到显著的细胞毒性。
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