Percie du Sert Nathalie, Bamsey Ian, Bate Simon T, Berdoy Manuel, Clark Robin A, Cuthill Innes, Fry Derek, Karp Natasha A, Macleod Malcolm, Moon Lawrence, Stanford S Clare, Lings Brian
National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), London, United Kingdom.
Certus Technology Associates Ltd, Exeter, United Kingdom.
PLoS Biol. 2017 Sep 28;15(9):e2003779. doi: 10.1371/journal.pbio.2003779. eCollection 2017 Sep.
Addressing the common problems that researchers encounter when designing and analysing animal experiments will improve the reliability of in vivo research. In this article, the Experimental Design Assistant (EDA) is introduced. The EDA is a web-based tool that guides the in vivo researcher through the experimental design and analysis process, providing automated feedback on the proposed design and generating a graphical summary that aids communication with colleagues, funders, regulatory authorities, and the wider scientific community. It will have an important role in addressing causes of irreproducibility.
解决研究人员在设计和分析动物实验时遇到的常见问题，将提高体内研究的可靠性。本文介绍了实验设计助手（EDA）。EDA是一个基于网络的工具，可指导体内研究人员完成实验设计和分析过程，对提议的设计提供自动反馈，并生成有助于与同事、资助者、监管机构及更广泛科学界进行沟通的图形化总结。它在解决不可重复性问题方面将发挥重要作用。
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