体内研究报告中的偏倚风险：改进重点

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement.

作者信息

Macleod Malcolm R, Lawson McLean Aaron, Kyriakopoulou Aikaterini, Serghiou Stylianos, de Wilde Arno, Sherratt Nicki, Hirst Theo, Hemblade Rachel, Bahor Zsanett, Nunes-Fonseca Cristina, Potluru Aparna, Thomson Andrew, Baginskaite Julija, Egan Kieren, Vesterinen Hanna, Currie Gillian L, Churilov Leonid, Howells David W, Sena Emily S

机构信息

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.

Medical School, University Medical Centre, Utrecht, Netherlands.

出版信息

PLoS Biol. 2015 Oct 13;13(10):e1002273. doi: 10.1371/journal.pbio.1002273. eCollection 2015 Oct.

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.