体内研究报告中的偏倚风险：改进重点

Macleod Malcolm R, Lawson McLean Aaron, Kyriakopoulou Aikaterini, Serghiou Stylianos, de Wilde Arno, Sherratt Nicki, Hirst Theo, Hemblade Rachel, Bahor Zsanett, Nunes-Fonseca Cristina, Potluru Aparna, Thomson Andrew, Baginskaite Julija, Egan Kieren, Vesterinen Hanna, Currie Gillian L, Churilov Leonid, Howells David W, Sena Emily S

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.

Medical School, University Medical Centre, Utrecht, Netherlands.

PLoS Biol. 2015 Oct 13;13(10):e1002273. doi: 10.1371/journal.pbio.1002273. eCollection 2015 Oct.

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.

实验结果的可靠性取决于实验设计的严谨性。在此我们发现，在随机抽取的生命科学出版物样本中，降低偏倚风险的措施报告有限；在高影响力期刊上发表的研究中，随机化的报告显著较少；而在英国顶尖机构发表的出版物中，降低偏倚风险的措施报告极为有限。确定机构之间的差异，既可以作为衡量研究质量的指标，也可以作为机构提高研究质量努力的工具。