药物研发：提高临床前癌症研究标准。 - Suppr

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超能文献

Drug development: Raise standards for preclinical cancer research.

作者信息

Begley C Glenn, Ellis Lee M

机构信息

Hematology and Oncology Research, Amgen, Thousand Oaks, California 91359, USA.

出版信息

Nature. 2012 Mar 28;483(7391):531-3. doi: 10.1038/483531a.

DOI:10.1038/483531a

PMID:22460880

Abstract

摘要

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本文引用的文献

Drug development and clinical trials--the path to an approved cancer drug.药物研发和临床试验——获批癌症药物的必经之路。

Nat Rev Clin Oncol. 2012 Feb 28;9(4):215-22. doi: 10.1038/nrclinonc.2012.22.

Believe it or not: how much can we rely on published data on potential drug targets?信不信由你：我们能在多大程度上依赖已发表的关于潜在药物靶点的数据？

Nat Rev Drug Discov. 2011 Aug 31;10(9):712. doi: 10.1038/nrd3439-c1.

High drug attrition rates--where are we going wrong?高药物淘汰率——我们哪里出错了？

Nat Rev Clin Oncol. 2011 Mar 30;8(4):189-90. doi: 10.1038/nrclinonc.2011.34.

Raising the bar for cancer therapy models.提高癌症治疗模型的标准。

Nat Biotechnol. 2010 Jun;28(6):561-2. doi: 10.1038/nbt0610-561.

Do pressures to publish increase scientists' bias? An empirical support from US States Data.发表压力会增加科学家的偏见吗？来自美国各州数据的实证支持。

PLoS One. 2010 Apr 21;5(4):e10271. doi: 10.1371/journal.pone.0010271.

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