Vaessen T, van Nierop M, Decoster J, Delespaul P, Derom C, de Hert M, Jacobs N, Menne-Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin-Germeys I
KU Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Contextual Psychiatry, Kapucijnenvoer 35 bus 7001, 3000 Leuven, Belgium; Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and Neuroscience MHeNS, Maastricht University, 6200 MD Maastricht, The Netherlands.
KU Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Contextual Psychiatry, Kapucijnenvoer 35 bus 7001, 3000 Leuven, Belgium.
Eur Psychiatry. 2017 Sep;45:167-173. doi: 10.1016/j.eurpsy.2017.07.002. Epub 2017 Jul 26.
The aim of the current study was to replicate findings in adults indicating that higher sensitivity to stressful events is predictive of both onset and persistence of psychopathological symptoms in a sample of adolescents and young adults. In addition, we tested the hypothesis that sensitivity to mild stressors in particular is predictive of the developmental course of psychopathology.
We analyzed experience sampling and questionnaire data collected at baseline and one-year follow-up of 445 adolescent and young adult twins and non-twin siblings (age range: 15-34). Linear multilevel regression was used for the replication analyses. To test if affective sensitivity to mild stressors in particular was associated with follow-up symptoms, we used a categorical approach adding variables on affective sensitivity to mild, moderate and severe daily stressors to the model.
Linear analyses showed that emotional stress reactivity was not associated with onset (β=.02; P=.56) or persistence (β=-.01; P=.78) of symptoms. There was a significant effect of baseline symptom score (β=.53; P<.001) and average negative affect (NA: β=.19; P<.001) on follow-up symptoms. Using the categorical approach, we found that affective sensitivity to mild (β=.25; P<.001), but not moderate (β=-.03; P=.65) or severe (β=-.06; P=.42), stressors was associated with symptom persistence one year later.
We were unable to replicate previous findings relating stress sensitivity linearly to symptom onset or persistence in a younger sample. Whereas sensitivity to more severe stressors may reflect adaptive coping, high sensitivity to the mildest of daily stressors may indicate an increased risk for psychopathology.
本研究的目的是在青少年和青年样本中复制在成年人中得到的研究结果,即对应激事件的更高敏感性可预测精神病理症状的发作和持续存在。此外,我们检验了这样一个假设,即对轻度应激源的敏感性尤其可预测精神病理学的发展进程。
我们分析了445对青少年和青年双胞胎及非双胞胎兄弟姐妹(年龄范围:15 - 34岁)在基线和一年随访时收集的经验抽样和问卷调查数据。线性多水平回归用于复制分析。为了检验对轻度应激源的情感敏感性是否尤其与随访症状相关,我们采用了一种分类方法,在模型中加入了对轻度、中度和重度日常应激源的情感敏感性变量。
线性分析表明,情绪应激反应性与症状的发作(β = 0.02;P = 0.56)或持续存在(β = -0.01;P = 0.78)均无关。基线症状评分(β = 0.53;P < 0.001)和平均消极情绪(NA:β = 0.19;P < 0.001)对随访症状有显著影响。采用分类方法,我们发现对轻度应激源(β = 0.25;P < 0.001)而非中度(β = -0.03;P = 0.65)或重度(β = -0.06;P = 0.42)应激源的情感敏感性与一年后的症状持续存在相关。
我们未能在较年轻的样本中复制先前关于应激敏感性与症状发作或持续存在呈线性关系的研究结果。对更严重应激源的敏感性可能反映了适应性应对,而对最轻微日常应激源的高敏感性可能表明精神病理学风险增加。