Willis Gregory L, Freelance Christopher B
The Bronowski Institute of Behavioural Neuroscience, Coliban Medical Centre, 19 Jennings Street, Kyneton, Vic 3444, Australia.
The Bronowski Institute of Behavioural Neuroscience, Coliban Medical Centre, 19 Jennings Street, Kyneton, Vic 3444, Australia.
Brain Res. 2018 Jan 1;1678:203-213. doi: 10.1016/j.brainres.2017.09.027. Epub 2017 Sep 25.
The importance of circadian function in the aetiology, progression and treatment of Parkinson's disease is a topic of increasing interest to the scientific and clinical community. While clinical studies on this theme are relatively new and limited in number there are many preclinical studies which explore possible circadian involvement in Parkinson's disease and speculate as to the mechanism by which clinical benefit can be derived by manipulating the circadian system. The present review explores the sequelae of circadian related studies from a historical perspective and reveals mechanisms that may be involved in the aetiology and progression of the disease. A systematic review of these studies also sets the stage for understanding the basic neuroscientific approaches which have been applied and provides new direction from which circadian function can be explored.
昼夜节律功能在帕金森病的病因、进展和治疗中的重要性，是科学界和临床界越来越感兴趣的一个话题。虽然关于这一主题的临床研究相对较新且数量有限，但有许多临床前研究探讨了昼夜节律可能与帕金森病的关联，并推测了通过调节昼夜节律系统获得临床益处的机制。本综述从历史角度探讨了昼夜节律相关研究的后果，并揭示了可能参与该疾病病因和进展的机制。对这些研究的系统综述也为理解已应用的基础神经科学方法奠定了基础，并为探索昼夜节律功能提供了新的方向。
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