Billy Pierre-Alain, Parmeland Laurence, Brunette Sylvie, Lecordier Sophie, Pecquet Matthieu
Laboratoire de biologie médicale, Centre hospitalier Saint-Joseph-Saint-Luc, Lyon, France.
SSR Val Rosay, Saint-Didier-au-Mont-d'Or, France.
Ann Biol Clin (Paris). 2017 Oct 1;75(5):572-575. doi: 10.1684/abc.2017.1281.
We report the case of a 54-year-old man with metastatic pulmonary neuroendocrine tumor associated with major procalcitonin (PCT) elevation without sepsis. Three lines of antibiotic therapies were successively introduced but had no positive effect on PCT kinetic and disease progression. Under palliative care, increasing of PCT level was constant during the hospitalization, along with major asthenia and pain and metastatic progression. PCT is an excellent biological marker of bacterial infection, both sensitive and specific. Nevertheless, we highlight here the existence of a frequent association between neuroendocrine tumors and elevation of PCT in the absence of sepsis.
我们报告了一例54岁男性患者，患有转移性肺神经内分泌肿瘤，伴有降钙素原（PCT）显著升高但无脓毒症。先后采用了三线抗生素治疗，但对PCT动态变化和疾病进展均无积极影响。在姑息治疗期间，住院期间PCT水平持续升高，同时伴有严重乏力、疼痛和转移进展。PCT是细菌感染的优秀生物标志物，兼具敏感性和特异性。然而，我们在此强调，神经内分泌肿瘤与无脓毒症情况下PCT升高之间存在频繁关联。
