Neuroscience and Neuroengineering Center, Med-X Research Institute Shanghai Jiao Tong University, Shanghai, China.
Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Stroke Vasc Neurol. 2016 Oct 25;1(3):127-132. doi: 10.1136/svn-2016-000013. eCollection 2016 Sep.
Priapism refers to a condition with persistent abnormal erection of the penis, which is usually caused by disease or injury in the brain or spinal cord, or obstruction to the outflow of blood through the dorsal vein at the root of the penis, without sexual desires. The effect of cerebral ischaemia on sexual function is unknown. The aim of this study is to explore whether priapism occurs in adult mice. Furthermore, we examined the relationship between priapism and the region of infarct in the brain.
Adult male CD-1 mice who underwent permanent middle cerebral artery occlusion (pMCAO) were closely examined from 2 hours to 14 days postoperation.
We found that priapism occurs in ∼80% of the mice with pMCAO, which could persist up to 14 days. Further study has demonstrated that the occurrence of priapism is related to the infarct region: priapism is found only in mice with ischaemic injury extending to the hypothalamus and the hippocampus regions.
Our result suggested priapism may be used as a deep brain injury marker for evaluating brain injury in mice after pMCAO.
阴茎异常勃起是指一种持续异常勃起的状态，通常由大脑或脊髓的疾病或损伤，或阴茎根部背静脉血液流出受阻引起，与性欲无关。脑缺血对性功能的影响尚不清楚。本研究旨在探讨成年小鼠是否会发生阴茎异常勃起，并研究阴茎异常勃起与脑梗死部位之间的关系。
对行永久性大脑中动脉闭塞（pMCAO）的成年雄性 CD-1 小鼠进行密切观察，从术后 2 小时到 14 天。
我们发现约 80%的 pMCAO 小鼠发生阴茎异常勃起，可持续至 14 天。进一步的研究表明，阴茎异常勃起的发生与梗死区域有关：只有在缺血损伤延伸至下丘脑和海马区域的小鼠中才会发生阴茎异常勃起。
我们的结果表明，阴茎异常勃起可能可作为评估 pMCAO 后小鼠大脑损伤的深部脑损伤标志物。
