红茶、绿茶和乌龙茶提取物对人头颈部鳞状癌细胞增殖的抑制作用。
Inhibitory effect of , and tea extracts on the proliferation of human head and neck squamous carcinoma cells.
作者信息
Ramirez-Mares Marco Vinicio, Kobayashi Hideka, de Mejia Elvira Gonzalez
机构信息
Instituto de Recursos, Universidad del Mar, Ciudad Universitaria, Puerto Ángel, CP 70902 Oaxaca, México.
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 228 ERML, MC-051, 1201 W. Gregory Drive, Urbana, IL 61801,USA.
出版信息
Toxicol Rep. 2016 Feb 1;3:269-278. doi: 10.1016/j.toxrep.2016.01.013. eCollection 2016.
cell proliferation, cell cycle arrest and induction of apoptosis were investigated, using three human head and neck squamous cell carcinoma (HNSCC) cell lines (OSCC-3, SCC-61, and SQ-20B). Aqueous extracts of , , and were tested and (-) epigallocatechin-3-gallate (EGCG) was used for comparison. For EGCG the IC values were between 80 and 166 μM and for the extracts among 75 and 505 μM eq. (+) catechin, with demonstrating dominant cytotoxicity. There was not a correlation between antioxidant capacity and cytotoxicity. Flow cytometry analysis revealed similarities in response for EGCG and . The extract altered DNA distribution ( < 0.05) and was the most effective in induction of apoptosis caspases ( < 0.05). Not all HNSCC cells tested responded to the same preventive agents. The fact that inhibits HNSCC cell proliferation makes this aqueous extract a potential source of chemopreventive agents.
使用三种人头颈部鳞状细胞癌（HNSCC）细胞系（OSCC - 3、SCC - 61和SQ - 20B）研究细胞增殖、细胞周期阻滞和细胞凋亡诱导情况。测试了[此处原文缺失具体提取物名称]的水提取物，并使用（-）表没食子儿茶素 - 3 - 没食子酸酯（EGCG）作为对照。对于EGCG，IC值在80至166μM之间，对于提取物，IC值在75至505μM当量（+）儿茶素之间，[此处原文缺失具体提取物名称]表现出显著的细胞毒性。抗氧化能力与细胞毒性之间没有相关性。流式细胞术分析显示EGCG和[此处原文缺失具体提取物名称]的反应相似。[此处原文缺失具体提取物名称]提取物改变了DNA分布（P < 0.05），并且在诱导凋亡半胱天冬酶方面最有效（P < 0.05）。并非所有测试的HNSCC细胞对相同的预防剂都有反应。[此处原文缺失具体提取物名称]抑制HNSCC细胞增殖这一事实使得这种水提取物成为化学预防剂的潜在来源。
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