Department of Chemistry and Biochemistry, National Chung Cheng University , Minhsiung 621, Taiwan.
Org Lett. 2017 Oct 20;19(20):5549-5552. doi: 10.1021/acs.orglett.7b02645. Epub 2017 Sep 29.
Total synthesis of the proposed structure of (±)-nidemone has been accomplished either from 2-hydroxy-6-methoxybenzaldehyde (7) or 2-bromo-6-methoxybenzaldehyde (8) in 10 and 13 synthetic steps, respectively. Sonogashira coupling, regioselective hydrogenation, and an intramolecular Stetter reaction were the key steps in the synthesis.
（±）-尼地莫的提议结构的全合成已经分别从 2-羟基-6-甲氧基苯甲醛（7）或 2-溴-6-甲氧基苯甲醛（8）经 10 步和 13 步合成完成。Sonogashira 偶联、区域选择性氢化和分子内 Stetter 反应是合成的关键步骤。
