Department of Chemistry and Biochemistry, National Chung Cheng University, Minhsiung 621, Taiwan.
Org Biomol Chem. 2018 Jul 11;16(27):4990-4995. doi: 10.1039/c8ob01207e.
Total synthesis of the revised structure of (±)-nidemone has been accomplished from 6-bromo-2-hydroxybenzaldehyde (5) in either six or eight synthetic steps in 6% and 10% overall yield, respectively, without using any protecting group. The revised structure of nidemone was confirmed by single-crystal X-ray diffraction analysis. Sonogashira coupling, regioselective hydrogenation, and an intramolecular Stetter reaction were the key steps in the synthesis.
（±）-尼地莫的修订结构的全合成已从 6-溴-2-羟基苯甲醛（5）完成，分别在六步和八步合成中以 6%和 10%的总收率得到，且未使用任何保护基。尼地莫的修订结构通过单晶 X 射线衍射分析得到证实。Sonogashira 偶联、区域选择性加氢和分子内 Stetter 反应是合成的关键步骤。
