Tran Nam T, Clavarino Alexandra, Williams Gail M, Najman Jake M
a ARC Centre of Excellence for Children and Families over the Life Course (Life Course Centre), Institute for Social Science Research , The University of Queensland , Brisbane , Queensland , Australia.
b Department of Sociology , Academy of Journalism and Communication , Hanoi , Vietnam.
Subst Use Misuse. 2018 Apr 16;53(5):705-715. doi: 10.1080/10826084.2017.1363233. Epub 2017 Sep 29.
There is little known about the extent to which maternal alcohol consumption influences offspring's alcohol use disorder. This study aims to examine whether different maternal alcohol consumption trajectories predict gender difference in adolescent alcohol use disorder at child age 21 years.
Data are from a prospective cohort, the Mater-University of Queensland Study of Pregnancy (MUSP) and its outcomes. The study involves 2531 mother-child pairs for whom data are available at the 21-year follow-up survey. Maternal alcohol consumption trajectories were determined by group-based trajectory modelling. Offspring's lifetime ever alcohol use disorder was assessed using DSM-IV diagnostic criteria.
Over 14 years of follow-up after the birth of a child, three distinct alcohol consumption trajectories were identified (abstainer, low-stable. and moderate-escalating drinker). A maternal trajectory of moderate-escalating alcohol consumption independently predicted offspring's lifetime ever alcohol use disorder at 21 years after adjustment for a range of potential confounders. "Cross-gender influence" is observed in the study.
A maternal life course pattern of alcohol consumption may have an independent effect on offspring alcohol consumption, with male offspring being more vulnerable to the effects of maternal alcohol use than are female offspring. Programs intended to address alcohol consumption by adolescents and young adults need to focus on the behaviors of both parents but acknowledging that maternal patterns of alcohol consumption may be particularly important for male offspring.
关于孕期母亲饮酒对后代酒精使用障碍的影响程度，目前所知甚少。本研究旨在探讨不同的孕期母亲饮酒轨迹是否能预测孩子21岁时青少年酒精使用障碍的性别差异。
数据来自一项前瞻性队列研究——昆士兰大学母亲孕期研究（MUSP）及其随访结果。该研究纳入了2531对母婴对，在21年随访调查中有可用数据。孕期母亲饮酒轨迹通过基于群组的轨迹模型确定。后代终生酒精使用障碍依据《精神疾病诊断与统计手册》第四版（DSM-IV）诊断标准进行评估。
在孩子出生后的14年随访中，确定了三种不同的饮酒轨迹（戒酒者、低稳定饮酒者和中度递增饮酒者）。在对一系列潜在混杂因素进行调整后，母亲中度递增饮酒轨迹独立预测了孩子21岁时的终生酒精使用障碍。本研究观察到了“跨性别影响”。
母亲饮酒的生活历程模式可能对后代饮酒有独立影响，男性后代比女性后代更容易受到母亲饮酒行为的影响。旨在解决青少年和年轻人饮酒问题的项目需要关注父母双方的行为，但要认识到母亲的饮酒模式可能对男性后代尤为重要。
