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小儿肥胖症手术后特发性颅内高压的分流独立性和临床缓解:3例报告

Shunt freedom and clinical resolution of idiopathic intracranial hypertension after bariatric surgery in the pediatric population: report of 3 cases.

作者信息

Hoang Kimberly B, Hooten Kristopher G, Muh Carrie R

机构信息

1Department of Neurosurgery, Duke University, Durham, North Carolina; and.

2Department of Neurosurgery, University of Florida, Gainesville, Florida.

出版信息

J Neurosurg Pediatr. 2017 Dec;20(6):511-516. doi: 10.3171/2017.6.PEDS17145. Epub 2017 Sep 29.

Abstract

Idiopathic intracranial hypertension (IIH), formerly known as pseudotumor cerebri, is a disease of elevated intracranial pressure that is thought to develop due to impaired CSF absorption related to elevated venous sinus pressure in the setting of increased intraabdominal and thoracic pressures. Symptoms can be disabling and, if left untreated, can lead to permanent visual loss. Previous treatments directed toward vision preservation include CSF diversion through shunting and optic nerve sheath fenestration. Recently, attention has been turned toward surgical weight loss strategies as an alternative to shunt treatment. The authors present a report of 3 patients with adolescent-onset IIH that was treated at the authors' institution (Duke University) in whom bariatric surgery was pursued successfully. The patients had previously undergone CSF shunting at ages 12, 15, and 23 years. They were shunt dependent for a collective average of 3.3 years prior to bariatriwc surgery. All patients reported "low-pressure" or postural headaches after bariatric surgery that correlated with dramatic reduction in their weight. Two of the 3 patients had their shunts removed and continued to be shunt free 1.5 years later at last follow-up; the third patient remained shunt dependent with the pressure set at 200 mm HO. Given the significant complications inherent to multiple shunt revisions, earlier intervention for weight loss, including bariatric surgery, in these patients might have prevented complications and the associated health care burden. The authors recommend a multidisciplinary approach for IIH treatment with early consideration for weight loss interventions in select patients.

摘要

特发性颅内高压(IIH),既往称为假性脑瘤,是一种颅内压升高的疾病,被认为是在腹内压和胸内压升高的情况下,由于与静脉窦压力升高相关的脑脊液吸收受损而发展而来。症状可能使人致残,若不治疗,可导致永久性视力丧失。以往旨在保护视力的治疗方法包括通过分流术进行脑脊液引流和视神经鞘开窗术。最近,人们的注意力转向了手术减肥策略,将其作为分流治疗的替代方法。作者报告了3例青少年起病的IIH患者,他们在作者所在机构(杜克大学)接受治疗,成功接受了减肥手术。这些患者曾在12岁、15岁和23岁时接受过脑脊液分流术。在接受减肥手术前,他们平均依赖分流术3.3年。所有患者在减肥手术后均报告有“低压性”或体位性头痛,这与体重显著减轻有关。3例患者中有2例在最后一次随访时于1.5年后移除了分流管,此后一直未再使用分流管;第3例患者仍依赖分流管,压力设定为200 mmH₂O。鉴于多次分流管翻修存在显著并发症,对这些患者尽早进行减肥干预,包括减肥手术,可能会预防并发症及相关的医疗负担。作者建议采用多学科方法治疗IIH,对特定患者尽早考虑减肥干预措施。

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