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Aryl hydrocarbon receptor (AhR) transcription is decreased in skin of vitiligo patients.

作者信息

Rekik Raja, Ben Hmid Ahlem, Lajnef Chayma, Zamali Imen, Zaraa Ines, Ben Ahmed Mélika

机构信息

Laboratory of Transmission, Control and Immunobiology of Infection, LR11IPT02, Institut Pasteur de Tunis, Tunis, Tunisia.

Laboratory of Clinical Immunology, Institut Pasteur de Tunis, Tunis, Tunisia.

出版信息

Int J Dermatol. 2017 Dec;56(12):1509-1512. doi: 10.1111/ijd.13761. Epub 2017 Sep 27.

DOI:10.1111/ijd.13761
PMID:28960282
Abstract
摘要

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1
Aryl hydrocarbon receptor (AhR) transcription is decreased in skin of vitiligo patients.白癜风患者皮肤中芳烃受体（AhR）转录水平降低。
Int J Dermatol. 2017 Dec;56(12):1509-1512. doi: 10.1111/ijd.13761. Epub 2017 Sep 27.
2
Vitiligo patients show significant up-regulation of aryl hydrocarbon receptor transcription factor.白癜风患者表现出芳烃受体转录因子的显著上调。
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Dysregulated tryptophan metabolism and AhR pathway contributed to CXCL10 upregulation in stable non-segmental vitiligo.色氨酸代谢失调和 AhR 通路导致稳定非节段性白癜风中 CXCL10 的上调。
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AHR promoter variant modulates its transcription and downstream effectors by allele-specific AHR-SP1 interaction functioning as a genetic marker for vitiligo.芳烃受体（AHR）启动子变体通过等位基因特异性的AHR-SP1相互作用调节其转录及下游效应分子，该相互作用作为白癜风的遗传标记发挥作用。
Sci Rep. 2015 Sep 15;5:13542. doi: 10.1038/srep13542.
5
The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations.芳香烃受体（AHR）基因功能多态性与汉族人群白癜风发病风险的关联。
Br J Dermatol. 2012 May;166(5):1081-7. doi: 10.1111/j.1365-2133.2011.10798.x.
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The role of aryl hydrocarbon receptor in vitiligo: a review.芳香烃受体在白癜风中的作用：综述。
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miRNA signatures and transcriptional regulation of their target genes in vitiligo.白癜风中miRNA特征及其靶基因的转录调控
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Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures.芳烃受体和芳烃受体核转位蛋白在人胎盘和大鼠胎盘的表达及人滋养层细胞培养物中的转录活性。
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Inhibition of AHR transcription by NF1C is affected by a single-nucleotide polymorphism, and is involved in suppression of human uterine endometrial cancer.NF1C 抑制 AHR 转录受单核苷酸多态性影响，并参与抑制人子宫内膜癌。
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MYG1, novel melanocyte related gene, has elevated expression in vitiligo.MYG1，一种新型黑素细胞相关基因，在白癜风中表达升高。
J Dermatol Sci. 2006 Nov;44(2):119-22. doi: 10.1016/j.jdermsci.2006.08.001. Epub 2006 Sep 22.

引用本文的文献

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Beyond skin deep: exploring the complex molecular mechanisms and holistic management strategies of vitiligo.深入探究白癜风：探索其复杂的分子机制与整体管理策略
Arch Dermatol Res. 2025 Apr 8;317(1):685. doi: 10.1007/s00403-025-04162-6.
2
Molecular insights of vitamin D receptor SNPs and vitamin D analogs: a novel therapeutic avenue for vitiligo.维生素D受体单核苷酸多态性与维生素D类似物的分子见解：白癜风的一种新治疗途径。
Mol Divers. 2025 Mar 21. doi: 10.1007/s11030-025-11168-9.
3
The role of aryl hydrocarbon receptor agonists in the treatment of vitiligo.
芳基烃受体激动剂在白癜风治疗中的作用。
Arch Dermatol Res. 2024 Oct 5;316(9):659. doi: 10.1007/s00403-024-03405-2.
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The role of aryl hydrocarbon receptor in vitiligo: a review.芳香烃受体在白癜风中的作用：综述。
Front Immunol. 2024 Feb 1;15:1291556. doi: 10.3389/fimmu.2024.1291556. eCollection 2024.
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A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes.色氨酸衍生的 AhR 配体在皮肤生理和病理过程中的潜在作用的新见解。
Int J Mol Sci. 2021 Jan 22;22(3):1104. doi: 10.3390/ijms22031104.
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Reciprocal regulation of interleukin-17A and interleukin-22 secretion through aryl hydrocarbon receptor activation in CD4 T cells of patients with vitiligo.白癜风患者CD4 T细胞中通过芳烃受体激活对白细胞介素-17A和白细胞介素-22分泌的相互调节
Exp Ther Med. 2021 Feb;21(2):158. doi: 10.3892/etm.2020.9589. Epub 2020 Dec 17.
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Astragaloside IV Enhances Melanogenesis via the AhR-Dependent AKT/GSK-3/-Catenin Pathway in Normal Human Epidermal Melanocytes.黄芪甲苷IV通过芳烃受体依赖的AKT/GSK-3/β-连环蛋白途径增强正常人表皮黑素细胞的黑素生成。
Evid Based Complement Alternat Med. 2020 Dec 15;2020:8838656. doi: 10.1155/2020/8838656. eCollection 2020.