新岩藻毒素对牛肾上腺嗜铬细胞诱发儿茶酚胺分泌的影响。
The effects of neosurugatoxin on evoked catecholamine secretion from bovine adrenal chromaffin cells.
作者信息
Bourke J E, Bunn S J, Marley P D, Livett B G
机构信息
Department of Biochemistry, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Br J Pharmacol. 1988 Feb;93(2):275-80. doi: 10.1111/j.1476-5381.1988.tb11431.x.
Abstract
- The effect of neosurugatoxin (NSTX), a toxin from the Japanese ivory mollusc (Babylonia japonica), on the nicotinic response of bovine adrenal chromaffin cells was examined. 2. NSTX inhibited acetylcholine- and nicotine-induced catecholamine secretion from the cultured cells with an IC50 against 5 microM nicotine of 30 nM. 3. This inhibitory effect was reversible and independent of the presence of agonist. 4. NSTX had no effect on the catecholamine release from cultured cells evoked by 50 mM K+, or 1 microM histamine. 5. NSTX had no effect on the stimulation of phosphatidylinositol metabolism evoked by 100 microM muscarine. 6. These results suggest NSTX may be useful as a nicotinic receptor probe in tissues such as the adrenal and sympathetic ganglia where alpha-bungarotoxin is ineffective.
摘要
- 研究了源自日本象牙贝（Babylonia japonica）的新岩蛤毒素（NSTX）对牛肾上腺嗜铬细胞烟碱反应的影响。2. NSTX抑制培养细胞中乙酰胆碱和尼古丁诱导的儿茶酚胺分泌，对5 microM尼古丁的IC50为30 nM。3. 这种抑制作用是可逆的，且与激动剂的存在无关。4. NSTX对50 mM K+或1 microM组胺诱发的培养细胞儿茶酚胺释放没有影响。5. NSTX对100 microM毒蕈碱诱发的磷脂酰肌醇代谢刺激没有影响。6. 这些结果表明，在α-银环蛇毒素无效的组织如肾上腺和交感神经节中，NSTX可能作为烟碱受体探针有用。
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