Younge Kelly C, Kuchta John R, Mikell Justin K, Rosen Benjamin, Bredfeldt Jeremy S, Matuszak Martha M
Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, MI, USA.
J Appl Clin Med Phys. 2017 Nov;18(6):97-103. doi: 10.1002/acm2.12197. Epub 2017 Sep 27.
Advanced radiotherapy delivery systems designed for high-dose, high-precision treatments often come equipped with high-definition multi-leaf collimators (HD-MLC) aimed at more finely shaping radiation dose to the target. In this work, we study the effect of a high definition MLC on spine stereotactic body radiation therapy (SBRT) treatment plan quality and plan deliverability.
Seventeen spine SBRT cases were planned with VMAT using a standard definition MLC (M120), HD-MLC, and HD-MLC with an added objective to reduce monitor units (MU). M120 plans were converted into plans deliverable on an HD-MLC using in-house software. Plan quality and plan deliverability as measured by portal dosimetry were compared among the three types of plans.
Only minor differences were noted in plan quality between the M120 and HD-MLC plans. Plans generated with the HD-MLC tended to have better spinal cord sparing (3% reduction in maximum cord dose). HD-MLC plans on average had 12% more MU and 55% greater modulation complexity as defined by an in-house metric. HD-MLC plans also had significantly degraded deliverability. Of the VMAT arcs measured, 94% had lower gamma passing metrics when using the HD-MLC.
Modest improvements in plan quality were noted when switching from M120 to HD-MLC at the expense of significantly less accurate deliverability in some cases.
为高剂量、高精度治疗设计的先进放射治疗输送系统通常配备高清多叶准直器(HD-MLC),旨在更精确地将辐射剂量塑形至靶区。在本研究中,我们探讨了高清MLC对脊柱立体定向体部放射治疗(SBRT)治疗计划质量和计划可交付性的影响。
对17例脊柱SBRT病例采用容积调强弧形放疗(VMAT)技术,分别使用标准定义MLC(M120)、HD-MLC以及增加了减少监测单位(MU)目标的HD-MLC进行计划制定。使用内部软件将M120计划转换为可在HD-MLC上执行的计划。比较三种类型计划的计划质量以及通过门静脉剂量测定法测量的计划可交付性。
M120计划和HD-MLC计划在计划质量上仅存在细微差异。使用HD-MLC生成的计划往往对脊髓的保护更好(脊髓最大剂量降低3%)。HD-MLC计划平均MU多12%且由内部指标定义的调制复杂度高55%。HD-MLC计划的可交付性也显著降低。在测量的VMAT弧中,使用HD-MLC时94%的弧的伽马通过率较低。
从M120切换到HD-MLC时,计划质量有适度改善,但在某些情况下代价是可交付性显著降低。