National Centre of Epidemiology, CIBER Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III (ISCIII), Madrid, Spain.
Influenza Other Respir Viruses. 2018 Jan;12(1):161-170. doi: 10.1111/irv.12499. Epub 2017 Dec 15.
Estimating the national burden of influenza disease is challenging. We aimed to estimate the disease burden of seasonal influenza in Spain, at the primary care and hospital level, over the 6 influenza seasons after 2009 pandemic.
We used data from the Spanish Influenza Sentinel Surveillance System to estimate weekly influenza rates and the number of influenza-like illness (ILI) and mild confirmed influenza cases (MCIC). From the surveillance of severe hospitalized confirmed influenza cases (SHCIC), we obtained hospitalization rates and total number of SHCIC, intensive care unit (ICU) admissions and deaths in influenza hospitalized patients. We estimated both mild and severe influenza cases, overall, and by age-group (<5, 5-14, 15-64, and ≥65 years).
The highest cumulative rates of MCIC were observed in <15 years (1395-3155 cases/100 000 population in 5-14 years) and the lowest in ≥65 years (141-608 cases/100 000 population). SHCIC rates revealed a characteristic U-shaped distribution, with annual average hospitalization rates of 16.5 and 18.9 SHCIC/100, 000 p in 0-4 years, and ≥65 years, respectively. We estimated an annual average of 866 868 cases of ILI attended in primary care (55% were MCIC), 3616 SHCIC, 1232 ICU admissions, and 437 deaths in SHCIC. The percentage of ICU admission among SHCIC was highest at 15-64 years (42%), while the hospitalization fatality rate ranged from 1% in 0-4 years to 18% in ≥65 years.
The ongoing Spanish Influenza Surveillance System allowed obtaining crucial information regarding the impact of mild and severe influenza in Spain.
评估流感疾病的全国负担具有挑战性。我们旨在评估 2009 年大流行后 6 个流感季节西班牙初级保健和医院层面季节性流感的疾病负担。
我们使用西班牙流感哨点监测系统的数据来估计每周流感发病率以及流感样疾病（ILI）和轻度确诊流感病例（MCIC）的数量。通过对严重住院确诊流感病例（SHCIC）的监测，我们获得了住院率和总 SHCIC 数量、重症监护病房（ICU）入院和流感住院患者死亡人数。我们估计了所有年龄组（<5 岁、5-14 岁、15-64 岁和≥65 岁）的轻度和重度流感病例。
MCIC 的累积率最高见于<15 岁年龄组（5-14 岁为每 10 万人 1395-3155 例），最低见于≥65 岁年龄组（每 10 万人 141-608 例）。SHCIC 率呈现出典型的 U 形分布，0-4 岁和≥65 岁的年平均住院率分别为每 10 万人 16.5 和 18.9 例 SHCIC。我们估计每年有 866868 例 ILI 在初级保健就诊（55%为 MCIC），3616 例 SHCIC，1232 例 ICU 入院和 437 例 SHCIC 死亡。SHCIC 中 ICU 入院的比例在 15-64 岁年龄组最高（42%），而住院病死率范围从 0-4 岁的 1%到≥65 岁的 18%。
正在进行的西班牙流感监测系统使我们能够获得有关西班牙轻度和重度流感影响的关键信息。
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