Robertson Bruce, Burri Lena, Berge Kjetil
Charles River, Tranent, Edinburgh EH33 2NE, UK.
Aker BioMarine Antarctic AS, Fjordalléen 16, PO Box 1423 Vika, NO-0115 Oslo, Norway.
Toxicol Rep. 2014 Sep 28;1:764-776. doi: 10.1016/j.toxrep.2014.07.007. eCollection 2014.
The safety of krill oil was assessed in a subchronic toxicity study and in a genotoxicity test. In a 13-week study, rats were fed krill oil or control diets. There were no differences noted in body weight, food consumption or in the functional observation battery parameters in either gender. Differences in both haematology and clinical chemistry values were noted in the krill oil-treated groups. However these findings were of no toxicological significance. Significant decreases in absolute and covariant heart weight in some krill oil-treated animals were noted although no corresponding histological changes were observed. In addition, periportal microvesicular hepatocyte vacuolation was noted histologically in males fed 5% krill oil. This finding was not associated with other indications of hepatic dysfunction. Given that the effects of the 13-week toxicity study were non-toxic in nature, the no observed adverse effect level (NOAEL) for the conditions of this study was considered to be 5% krill oil. The genotoxicity experiments documented no mutagenicity of krill oil in bacteria.
在一项亚慢性毒性研究和一项遗传毒性试验中对磷虾油的安全性进行了评估。在一项为期13周的研究中，给大鼠喂食磷虾油或对照饮食。在体重、食物消耗或任何一种性别的功能观察组合参数方面均未发现差异。在磷虾油处理组中发现血液学和临床化学值存在差异。然而，这些发现没有毒理学意义。在一些磷虾油处理的动物中，观察到绝对心脏重量和协变心脏重量显著下降，尽管未观察到相应的组织学变化。此外，在喂食5%磷虾油的雄性大鼠中，组织学上观察到门静脉周围微泡性肝细胞空泡化。这一发现与肝功能障碍的其他指标无关。鉴于为期13周的毒性研究结果本质上无毒性，本研究条件下的未观察到有害作用水平（NOAEL）被认为是5%的磷虾油。遗传毒性实验证明磷虾油在细菌中无致突变性。
