激光诱导冲击波碎石术——纳秒脉冲的生物学效应

Laser induced shock wave lithotripsy--biologic effects of nanosecond pulses.

作者信息

Hofmann R, Hartung R, Geissdörfer K, Ascherl R, Erhardt W, Schmidt-Kloiber H, Reichel E

机构信息

Department of Urology, Technische Universität München, FRG.

出版信息

J Urol. 1988 May;139(5):1077-9. doi: 10.1016/s0022-5347(17)42790-x.

DOI:10.1016/s0022-5347(17)42790-x

PMID:2896253

Abstract

Laser energy of a Nd-YAG laser (1064 nm. wave length, 8 nsec pulse duration) was directed against various tissue cultures and the urothelium of the ureter, bladder and kidney parenchyma in pigs. Single pulse energy was 50 to 120 mJ with a repetition rate of 20 Hz. Urothelium and kidney parenchyma were irradiated in seven pigs. Tissue samples were examined histologically and electron microscopically directly, two, four, eight and 12 days after irradiation. No macroscopic lesion could be found. Maximum energy caused a small 'rupture cone' of 40 micron. depth. No thermic effects or necrosis resulted, so that no harm is to be expected with unintentional irradiation during laser stone disintegration.

摘要

将钕钇铝石榴石激光（波长1064纳米，脉冲持续时间8纳秒）的激光能量对准猪的各种组织培养物以及输尿管、膀胱和肾实质的尿路上皮。单脉冲能量为50至120毫焦，重复频率为20赫兹。对七头猪的尿路上皮和肾实质进行了照射。在照射后直接、2天、4天、8天和12天对组织样本进行了组织学和电子显微镜检查。未发现宏观病变。最大能量导致了一个深度为40微米的小“破裂锥”。未产生热效应或坏死，因此在激光碎石过程中意外照射预计不会造成伤害。