内体交通堵塞是阿尔茨海默病的致病枢纽和治疗靶点。
Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease.
作者信息
Small Scott A, Simoes-Spassov Sabrina, Mayeux Richard, Petsko Gregory A
机构信息
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA.
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA.
出版信息
Trends Neurosci. 2017 Oct;40(10):592-602. doi: 10.1016/j.tins.2017.08.003.
Abstract
While clues have existed that endosomal trafficking is associated with Alzheimer's disease (AD), whether it plays a central role in the disease and if so how has remained unknown. Here we rely on recent genetic and cellular findings to construct a model proposing that traffic jams in the early endosome can act as an upstream pathogenic hub in AD. We also rely on an independent series of findings to suggest how the traffic jams can act as a unified mediator of downstream pathophysiology. The model predicts, therefore, that interventions designed to unjam the endosome carry high therapeutic promise.
摘要
虽然已有线索表明内体运输与阿尔茨海默病（AD）相关，但它是否在该疾病中起核心作用，以及如果是这样其作用方式如何，仍然未知。在这里，我们依据最近的遗传学和细胞研究结果构建了一个模型，提出早期内体中的运输堵塞可作为AD的上游致病枢纽。我们还依据另一系列独立研究结果，来表明运输堵塞如何能够作为下游病理生理学的统一介导因素。因此，该模型预测，旨在疏通内体的干预措施具有很高的治疗前景。
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