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评估新的髋关节指数作为糖尿病风险预测指标。

Assessing a new hip index as a risk predictor for diabetes mellitus.

机构信息

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.

出版信息

J Diabetes Investig. 2018 Jul;9(4):799-805. doi: 10.1111/jdi.12756. Epub 2017 Nov 17.

Abstract

AIMS/INTRODUCTION: Recently, a new anthropometric parameter (a new hip index [HI]) was developed, and the HI shows a U-shaped relationship to mortality in the USA population. It is well known that there is an inverse relationship between hip circumference (HC) and the risk of diabetes mellitus. Accordingly, the study sought to investigate whether HI could predict future diabetes mellitus, as compared with HC and the waist-to-hip ratio (WHR), in a general Chinese population.

MATERIALS AND METHODS

In 2007, we carried out a health examination of 687 participants (mean age 48.1 ± 6.2 years, male 58.1%). Development of diabetes mellitus by the 2007 examination was studied in relation to data from a baseline health examination carried out in 1992.

RESULTS

During the follow up, 74 participants were diagnosed with diabetes mellitus. Across the quintiles of baseline HI, the incidence rates of diabetes mellitus were 12.4, 12.4, 9.9, 7.8 and 11.3% in quintile (Q)1, Q2, Q3, Q4 and Q5, respectively (P = 0.698). With the lowest quintile (Q1) as reference, univariate and multivariate Cox regression analyses showed that HI was not associated with diabetes mellitus. In contrast, HC and WHR could predict future diabetes mellitus. Furthermore, WHR had the best discriminatory power for diabetes mellitus (area under the receiver operating characteristic curve 0.691, 95% confidence interval 0.621-0.761), followed by HC (area under the receiver operating characteristic curve 0.623, 95% confidence interval 0.558-0.689) and HI (area under the receiver operating characteristic curve 0.464, 95% confidence interval 0.396-0.531).

CONCLUSIONS

Compared with HC and WHR, HI was not an independent risk factor for diabetes mellitus in the Chinese population. More studies are required to delineate the limits of the utility of HI.

摘要

目的/引言:最近,一种新的人体测量参数(新的髋指数[HI])被开发出来,并且在美国人群中,HI 与死亡率呈 U 型关系。众所周知,臀围(HC)与糖尿病风险呈反比关系。因此,本研究旨在探讨在一般中国人群中,与 HC 和腰臀比(WHR)相比,HI 是否可以预测未来的糖尿病。

材料和方法

2007 年,我们对 687 名参与者(平均年龄 48.1 ± 6.2 岁,男性 58.1%)进行了健康检查。通过 2007 年的检查研究了 1992 年基线健康检查时糖尿病的发展情况。

结果

在随访期间,有 74 名参与者被诊断患有糖尿病。在基线 HI 的五分位数中,第 1、2、3、4 和 5 五分位数的糖尿病发病率分别为 12.4%、12.4%、9.9%、7.8%和 11.3%(P = 0.698)。与最低五分位数(Q1)作为参考,单变量和多变量 Cox 回归分析表明 HI 与糖尿病无关。相比之下,HC 和 WHR 可以预测未来的糖尿病。此外,WHR 对糖尿病具有最佳的判别能力(接受者操作特征曲线下面积 0.691,95%置信区间 0.621-0.761),其次是 HC(接受者操作特征曲线下面积 0.623,95%置信区间 0.558-0.689)和 HI(接受者操作特征曲线下面积 0.464,95%置信区间 0.396-0.531)。

结论

与 HC 和 WHR 相比,HI 不是中国人群糖尿病的独立危险因素。需要进一步研究来描绘 HI 的应用范围。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9a1/6031512/929e9906b3b5/JDI-9-799-g001.jpg

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