BASF SE, Crop Protection - Ecotoxicology, Speyerer-Strasse 2, D-67117 Limburgerhof, Germany.
BASF SE, Crop Protection - Ecotoxicology, Speyerer-Strasse 2, D-67117 Limburgerhof, Germany.
Chemosphere. 2017 Dec;189:619-626. doi: 10.1016/j.chemosphere.2017.09.047. Epub 2017 Sep 12.
This paper presents a model to predict acute dermal toxicity of plant protection products (PPPs) to terrestrial amphibian life stages from (regulatory) fish data. By combining existing concepts, including interspecies correlation estimation (ICE), allometric relations, lethal body burden (LBB) and bioconcentration modelling, an equation was derived that predicts the amphibian median lethal dermal dose (LD) from standard acute toxicity values (96-h LC) for fish and bioconcentration factors (BCF) in fish. Where possible, fish BCF values were corrected to 5% lipid, and to parent compound. Then, BCF values were adjusted to an exposure duration of 96 h, in case steady state took longer to be achieved. The derived correlation equation is based on 32 LD values from acute dermal toxicity experiments with 15 different species of anuran amphibians, comprising 15 different PPPs. The developed ICE model can be used in a screening approach to estimate the acute risk to amphibian terrestrial life stages from dermal exposures to PPPs with organic active substances. This has the potential to reduce unnecessary testing of vertebrates.
本文提出了一个模型，用于从（监管）鱼类数据预测植物保护产品（PPPs）对陆生两栖动物生命阶段的急性皮肤毒性。通过结合现有概念，包括种间相关估计（ICE）、比例关系、致死体负荷（LBB）和生物浓缩模型，推导出一个方程，可根据鱼类的标准急性毒性值（96 小时 LC）和鱼类中的生物浓缩系数（BCF）预测两栖动物的中值致死皮肤剂量（LD）。在可能的情况下，将鱼类 BCF 值校正为 5%的脂质和母体化合物。然后，将 BCF 值调整为 96 小时的暴露时间，以防达到稳定状态需要更长时间。该相关方程是基于 32 种不同的两栖动物物种的 15 种不同 PPP 的急性皮肤毒性实验中的 15 种 LD 值得出的。开发的 ICE 模型可用于筛选方法，以估计 PPP 中有机活性物质对两栖动物陆地生命阶段的皮肤暴露的急性风险。这有可能减少对脊椎动物的不必要测试。
