Waitumbi J N, Brown H C, Jennings F W, Holmes P H
Kenya Trypanosomiasis Research Institute (KETRI), Muguga, Kikuyu.
Acta Trop. 1988 Mar;45(1):45-54.
Infections of T. brucei in the rabbit were found to relapse after chemotherapy. The results indicated that 25 mg/kg diminazene aceturate given 3 days after infection resulted in a complete cure but if given 7 days after infection relapses frequently occurred. However, treatment was apparently successful if delayed until 14 or 21 days. Six of the rabbits originally treated with diminazene aceturate on day 7 were treated with suramin 21 days later; in 3 rabbits the infections relapsed. In all rabbits in which drug treatment was not curative, the clinical condition nevertheless improved. An attempt to locate a cryptic focus of infection in rabbits was unsuccessful.
研究发现，兔感染布氏锥虫后经化疗会复发。结果表明，感染后3天给予25mg/kg乙酰氨基苯脒可实现完全治愈，但感染后7天给药则经常出现复发。然而，如果推迟到14天或21天治疗，显然会取得成功。最初在第7天用乙酰氨基苯脒治疗的6只兔子在21天后用苏拉明治疗；其中3只兔子感染复发。在所有药物治疗未治愈的兔子中，临床状况仍有改善。在兔子身上寻找隐匿感染灶的尝试未成功。
