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全球、区域和次区域不安全人工流产分类,2010-2014 年:贝叶斯层次模型估计。

Global, regional, and subregional classification of abortions by safety, 2010-14: estimates from a Bayesian hierarchical model.

机构信息

UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, Geneva, Switzerland.

Ibis Reproductive Health, Oakland, CA, USA.

出版信息

Lancet. 2017 Nov 25;390(10110):2372-2381. doi: 10.1016/S0140-6736(17)31794-4. Epub 2017 Sep 27.

Abstract

BACKGROUND

Global estimates of unsafe abortions have been produced for 1995, 2003, and 2008. However, reconceptualisation of the framework and methods for estimating abortion safety is needed owing to the increased availability of simple methods for safe abortion (eg, medical abortion), the increasingly widespread use of misoprostol outside formal health systems in contexts where abortion is legally restricted, and the need to account for the multiple factors that affect abortion safety.

METHODS

We used all available empirical data on abortion methods, providers, and settings, and factors affecting safety as covariates within a Bayesian hierarchical model to estimate the global, regional, and subregional distributions of abortion by safety categories. We used a three-tiered categorisation based on the WHO definition of unsafe abortion and WHO guidelines on safe abortion to categorise abortions as safe or unsafe and to further divide unsafe abortions into two categories of less safe and least safe.

FINDINGS

Of the 55· 7 million abortions that occurred worldwide each year between 2010-14, we estimated that 30·6 million (54·9%, 90% uncertainty interval 49·9-59·4) were safe, 17·1 million (30·7%, 25·5-35·6) were less safe, and 8·0 million (14·4%, 11·5-18·1) were least safe. Thus, 25·1 million (45·1%, 40·6-50·1) abortions each year between 2010 and 2014 were unsafe, with 24·3 million (97%) of these in developing countries. The proportion of unsafe abortions was significantly higher in developing countries than developed countries (49·5% vs 12·5%). When grouped by the legal status of abortion, the proportion of unsafe abortions was significantly higher in countries with highly restrictive abortion laws than in those with less restrictive laws.

INTERPRETATION

Increased efforts are needed, especially in developing countries, to ensure access to safe abortion. The paucity of empirical data is a limitation of these findings. Improved in-country data for health services and innovative research to address these gaps are needed to improve future estimates.

FUNDING

UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction; David and Lucile Packard Foundation; UK Aid from the UK Government; Dutch Ministry of Foreign Affairs; Norwegian Agency for Development Cooperation.

摘要

背景

全球对不安全堕胎的估计数是在 1995 年、2003 年和 2008 年编制的。然而,由于安全堕胎的简单方法(例如药物流产)的可用性增加,在法律限制堕胎的情况下,米索前列醇在正规卫生系统外的广泛使用,以及需要考虑影响堕胎安全的多种因素,因此需要对评估堕胎安全的框架和方法进行重新概念化。

方法

我们使用了所有关于堕胎方法、提供者和环境以及影响安全性的因素的现有经验数据,将这些因素作为协变量纳入贝叶斯层次模型中,以估计按安全类别划分的全球、区域和次区域堕胎分布情况。我们根据世卫组织对不安全堕胎的定义和世卫组织安全堕胎指南,采用了三级分类方法,将堕胎分为安全和不安全两类,并进一步将不安全堕胎分为不太安全和最不安全两类。

发现

在 2010-14 年期间,全球每年发生的 5570 万例堕胎中,我们估计其中 3060 万例(54.9%,90%置信区间 49.9-59.4)是安全的,1710 万例(30.7%,25.5-35.6)是不太安全的,800 万例(14.4%,11.5-18.1)是最不安全的。因此,每年有 2510 万例(45.1%,40.6-50.1)堕胎在 2010 年至 2014 年期间是不安全的,其中 2430 万例(97%)发生在发展中国家。发展中国家不安全堕胎的比例明显高于发达国家(49.5%对 12.5%)。按堕胎法律地位分组时,堕胎法律严格限制的国家的不安全堕胎比例明显高于堕胎法律限制较少的国家。

解释

需要加大努力,特别是在发展中国家,以确保获得安全堕胎。经验数据的缺乏是这些发现的一个局限性。需要改进国内卫生服务数据,并开展创新性研究,以解决这些差距,从而改善今后的估计。

资金

联合国开发计划署/联合国人口基金/联合国儿童基金会/世界卫生组织/世界银行生殖健康研究、发展和培训特别方案;戴维和露西尔·派克德基金会;英国国际发展部/英国政府;荷兰外交部;挪威发展合作署。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a530/5711001/37d2c85bb3fd/gr1.jpg

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