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2型糖尿病伴或不伴神经病变患者足底压力与血糖控制的关系

Relationship of planter pressure and glycemic control in type 2 diabetic patients with and without neuropathy.

作者信息

Halawa Mohammed R, Eid Yara M, El-Hilaly Rana A, Abdelsalam Mona M, Amer Amr H

机构信息

Department of Endocrinology and Metabolism, Faculty of Medicine, Ain Shams University Hospitals, Ramsis Street, Abbassia Square, Cairo, 11591, Egypt.

Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University Hospitals, Ramsis Street, Abbassia Square, Cairo, 11591, Egypt.

出版信息

Diabetes Metab Syndr. 2018 Apr-Jun;12(2):99-104. doi: 10.1016/j.dsx.2017.09.010. Epub 2017 Sep 23.

Abstract

INTRODUCTION

Foot disease is a common complication of type 2 diabetes that can have tragic consequences. Abnormal plantar pressures are considered to play a major role in the pathologies of neuropathic ulcers in the diabetic foot.

AIM

To examine Relationship of Planter Pressure and Glycemic Control in Type 2 Diabetic Patients with and without Neuropathy.

MATERIALS AND METHODS

The study was conducted on 50 type 2 diabetic patients and 30 healthy volunteers. BMI calculation, disease duration, Hemoglobin A1c and presence of neuropathy (by history, foot examination and DN4 questionnaire) were recorded. Plantar pressure was recorded for all patients using the Mat-scan (Tekscan, Inc.vers. 6.34 Boston USA) in static conditions (standing) and dynamic conditions (taking a step on the Mat-scan). Plantar pressures (kPa) were determined at the five metatarsal areas, mid foot area, medial and lateral heel areas and medial three toes.

RESULTS

Static and dynamic plantar pressures in both right and left feet were significantly higher in diabetic with neuropathy group than in control group in measured areas (P<0.05). Static and dynamic pressures in right and left feet were significantly higher in diabetic with neuropathy group than in diabetic without neuropathy group in measured areas (P<0.05). On comparison between controls and diabetic without neuropathy group there was a significant difference in plantar pressures especially in metatarsal areas (P<0.05). No significant correlations were present between the studied variables age, disease duration, BMI and HbA1c and plantar pressures in all studied areas.

CONCLUSION

Persons with diabetic neuropathy have elevated peak plantar pressure (PPP) compared to patients without neuropathy and control group. HbA1c% as a surrogate for glycemic control had no direct impact on peak planter pressure, yet it indirectly impacts neuropathy evolution through out disease duration eventually leading to the drastic planter pressure and gait biomechanics changes.

摘要

引言

足部疾病是2型糖尿病常见的并发症,可能会产生悲惨后果。足底压力异常被认为在糖尿病足神经性溃疡的发病机制中起主要作用。

目的

研究有无神经病变的2型糖尿病患者足底压力与血糖控制的关系。

材料与方法

对50例2型糖尿病患者和30名健康志愿者进行研究。记录体重指数计算结果、病程、糖化血红蛋白以及神经病变情况(通过病史、足部检查和DN4问卷)。使用Mat-scan(美国波士顿Tekscan公司,版本6.34)在静态条件(站立)和动态条件(在Mat-scan上行走一步)下记录所有患者的足底压力。在五个跖骨区域、足中部区域、内侧和外侧足跟区域以及内侧三个脚趾处测定足底压力(千帕)。

结果

在测量区域,糖尿病伴神经病变组左右脚的静态和动态足底压力均显著高于对照组(P<0.05)。在测量区域,糖尿病伴神经病变组左右脚的静态和动态压力显著高于无神经病变的糖尿病组(P<0.05)。对照组与无神经病变的糖尿病组相比,足底压力存在显著差异,尤其是在跖骨区域(P<0.05)。在所有研究区域,所研究的变量年龄、病程、体重指数和糖化血红蛋白与足底压力之间均无显著相关性。

结论

与无神经病变的患者及对照组相比,糖尿病神经病变患者的足底压力峰值升高。糖化血红蛋白百分比作为血糖控制的替代指标,对足底压力峰值没有直接影响,但它在整个病程中间接影响神经病变的进展,最终导致足底压力急剧变化和步态生物力学改变。

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