Indian Spinal Injuries Centre, Sector C, Vasant Kunj, New Delhi 110070, India.
Indian Spinal Injuries Centre, Sector C, Vasant Kunj, New Delhi 110070, India.
Adv Drug Deliv Rev. 2017 Oct 1;120:41-49. doi: 10.1016/j.addr.2017.09.021. Epub 2017 Sep 28.
Recent advances in basic science in research related to spinal cord injury (SCI) and regeneration have led to a variety of novel experimental therapeutics designed to promote functionally effective axonal regrowth and sprouting. Stem cell and other cellular interventions have gained lot of attention due to their immense potential of regeneration. These interventions have been tested for their efficacy in case of SCI both at the pre-clinical and clinical level. In this review we critically discuss the published literature on the cellular interventions for SCI and their clinical applications with respect to the strength of evidence established by these studies. The need to curb unethical practice of offering unproven stem cell "therapies" for SCI at a global level is also discussed.
近年来,与脊髓损伤 (SCI) 和再生相关的基础科学研究取得了进展,出现了多种旨在促进功能有效轴突再生和发芽的新型实验治疗方法。由于具有巨大的再生潜力,干细胞和其他细胞干预措施引起了广泛关注。这些干预措施已经在临床前和临床水平上对 SCI 的疗效进行了测试。在这篇综述中,我们批判性地讨论了有关 SCI 细胞干预及其临床应用的已发表文献,重点是这些研究确定的证据强度。还讨论了需要遏制在全球范围内对未经证实的干细胞“疗法”进行不道德的 SCI 治疗的做法。