Bieńkiewicz Jan, Romanowicz Hanna, Malinowski Andrzej, Smolarz Beata
Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mothers' Memorial Hospital-Research Institute, Lodz, Poland.
Department of Clinical Pathology, Polish Mothers' Memorial Hospital-Research Institute, Lodz, Poland.
Eur J Obstet Gynecol Reprod Biol. 2017 Nov;218:113-118. doi: 10.1016/j.ejogrb.2017.09.022. Epub 2017 Sep 22.
The aim of this study was to analyse the frequencies of genotypes and alleles of Single Nucleotide Polymorphism (SNP) -2548 G/A (rs12112075) of leptin gene (LEP) and an attempt to evaluate the effect this DNA marker has on endometrial cancer (EC) and uterine leiomyomas (UL).
The study comprised 120 patients treated for endometrial cancer and 90 patients treated for uterine leiomyomas. 90 disease-free individuals were used as controls. In total, 300 patients were investigated in this research.
In this paper we have demonstrated that genotype AG of SNP -2548 G/A of LEP may reduce the risk of developing endometrial cancer, whereas allele A itself may be a risk factor of this malignancy. No association was found between the studied polymorphism and uterine leiomyomas.
-2548 G/A SNP of LEP may play a significant role in the development of EC, however, uterine leiomyomas are not associated with this DNA marker.
本研究旨在分析瘦素基因（LEP）单核苷酸多态性（SNP）-2548 G/A（rs12112075）的基因型和等位基因频率，并尝试评估该DNA标记对子宫内膜癌（EC）和子宫平滑肌瘤（UL）的影响。
该研究包括120例接受子宫内膜癌治疗的患者和90例接受子宫平滑肌瘤治疗的患者。90名无病个体作为对照。本研究共调查了300名患者。
在本文中我们证明，LEP的SNP -2548 G/A的基因型AG可能降低患子宫内膜癌的风险，而等位基因A本身可能是这种恶性肿瘤的一个风险因素。在所研究的多态性与子宫平滑肌瘤之间未发现关联。
LEP的-2548 G/A SNP可能在EC的发生发展中起重要作用，然而，子宫平滑肌瘤与该DNA标记无关。
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