Kitamura Shinji, Muguruma Naoki, Okamoto Koichi, Tanahashi Toshihito, Fukuya Akira, Tanaka Kumiko, Fujimoto Daisaku, Kimura Tetsuo, Miyamoto Hiroshi, Bando Yoshimi, Takeuchi Hisashi, Shiba Masako, Takayama Tetsuji
Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Digestion. 2017 Nov;96(4):199-206. doi: 10.1159/000481346. Epub 2017 Sep 30.
BACKGROUND/AIMS: Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas.
A total of 91 patients who were diagnosed as having early gastric cancer were enrolled. We evaluated the gastritis status using scores for gastritis and atrophy, positivity of H. pylori infection, the prevalence rate of xanthomas, and the clinicopathological features of gastric cancer.
Gastric xanthomas were observed in 72.5% of early gastric cancer cases. Scores for gastritis and atrophy were significantly higher in the xanthoma-positive group than those in the xanthoma-negative group. A higher prevalence of differentiated-type adenocarcinoma was found in the xanthoma-positive group. Among the cases with multiple gastric xanthomas, the prevalence of males was significantly higher than that of females.
A high prevalence rate of gastric xanthomas in gastric cancer cases was shown. Xanthomas were highly associated with age, the severities of gastritis and atrophy, and differentiated-type adenocarcinoma. Regardless of the eradication of H. pylori, xanthomas may be useful predictive markers for the development of differentiated-type adenocarcinoma.
背景/目的：胃黄色瘤在胃内常表现为小黄斑或小结节。已有报道称幽门螺杆菌感染、萎缩性胃炎与黄色瘤之间存在密切关系。我们评估了伴有或不伴有黄色瘤的胃癌的临床病理特征。
共纳入91例被诊断为早期胃癌的患者。我们使用胃炎和萎缩评分、幽门螺杆菌感染阳性率、黄色瘤患病率以及胃癌的临床病理特征来评估胃炎状况。
72.5%的早期胃癌病例中观察到胃黄色瘤。黄色瘤阳性组的胃炎和萎缩评分显著高于黄色瘤阴性组。黄色瘤阳性组中分化型腺癌的患病率更高。在有多发性胃黄色瘤的病例中，男性患病率显著高于女性。
胃癌病例中胃黄色瘤的患病率较高。黄色瘤与年龄、胃炎和萎缩的严重程度以及分化型腺癌高度相关。无论幽门螺杆菌是否根除，黄色瘤可能是分化型腺癌发生的有用预测标志物。
